Linda J KENNEY
Alumni, Mechanobiology Institute, National University of Singapore
Seeking Head of Microfabrication Core Facility at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS, seeks to recruit a Facility Manager to heads its Microfabrication Core Facility.
Seeking Postdoctoral Research Fellow (Biomaterials and Mechanobiology) in the group of Asst. Prof. Jennifer Young at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS, seeks to recruit a Postdoctoral Research Fellow (Biomaterials and Mechanobiology) in the group of Asst. Prof. Jennifer Young.
Seeking Postdoctoral Research Fellow (Spatial Omics) in the group of Asst. Prof. Jennifer Young at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS, seeks to recruit a Postdoctoral Research Fellow (Spatial Omics) in the group of Asst. Prof. Jennifer Young.
Congrats to Kelly and Gefei for passing their Qualifying Exams!
Looking forward to the exciting science ahead!
Linda J Kenney
Alumni
Research Areas
Signal transduction in bacteria; Bacterial Pathogenesis; Mechanotransduction and osmotic signaling in E. coli; Mechanisms of anti-silencing of virulence genes in Salmonella
Research Interests
Our laboratory is interested in signal transduction and the regulation of gene expression in prokaryotes. In particular, we are studying the two-component regulatory system EnvZ/OmpR that regulates the expression of outer membrane proteins as well as many other genes. Our present work focuses on how OmpR activates genes required for systemic infection (located on Salmonella pathogenicity island 2) in Salmonella enterica.
The Kenney Lab’s research was recently featured in an article exploring the bacterial molecular switch between virulence or dormancy, Salmonella Lifestyle Choices. Members of her lab have discovered that the bacterial protein SsrB is the molecular switch for determining whether Salmonella infections become acute and virulent, or remain in a dormant carrier state.
The study is published in eLife (Desai et al., The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing, February 2, 2016, eLife 2016; 5: e10747, doi: 10.7554/eLife.10747). Read full article.
Biography
Dr Kenney is a Professor of Microbiology at the University of Illinois-Chicago. Her laboratory studies two-component systems in bacteria that control gene expression at a single cell and nanometer level.
Professor Linda J Kenney and Professor Michael Sheetz interviewed by the Washington Post at the April 2017 March for Science.
Education
PhD University of Pennsylvania
Recent Publications
- Fernandez M, Yamanaka Y, Zangoui P, White MA, and Kenney LJ. The sulfur assimilation pathway mitigates redox stress from acidic pH in Salmonella Typhi H58. mBio 2025;:e0046725. [PMID: 40422406]
- Shetty D, and Kenney LJ. A pH-sensitive switch activates virulence in Salmonella. Elife 2023; 12. [PMID: 37706506]
- Oh D, Liu X, Sheetz MP, and Kenney LJ. Small, Dynamic Clusters of Tir-Intimin Seed Actin Polymerization. Small 2023;:e2302580. [PMID: 37649226]
- Mon KKZ, Si Z, Chan-Park MB, and Kenney LJ. Polyimidazolium Protects against an Invasive Clinical Isolate of Salmonella Typhimurium. Antimicrob Agents Chemother 2022;:e0059722. [PMID: 36094258]
- Jacob H, Geng H, Shetty D, Halow N, Kenney LJ, and Nakano MM. Distinct Interaction Mechanism of RNAP and ResD and Distal Subsites for Transcription Activation of Nitrite Reductase in Bacillus subtilisψ. J Bacteriol 2021;:JB0043221. [PMID: 34898263]
- Singh MK, Zangoui P, Yamanaka Y, and Kenney LJ. Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors. Elife 2021; 10. [PMID: 34061032]
- Kenney LJ, and Anand GS. EnvZ/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically. EcoSal Plus 2020; 9(1). [PMID: 32003321]
- Desai SK, and Kenney LJ. Switching Lifestyles Is an in vivo Adaptive Strategy of Bacterial Pathogens. Front Cell Infect Microbiol 2019; 9:421. [PMID: 31921700]
- Desai SK, Padmanabhan A, Harshe S, Zaidel-Bar R, and Kenney LJ. Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2019;. [PMID: 31160462]
- Ottemann KM, and Kenney LJ. Editorial overview: Host-pathogen interactions: bacteria. Curr. Opin. Microbiol. 2019; 47:iii-v. [PMID: 31138403]
Lab Members
Miguel SOON Jun Yi
PhD Student, Class of August 2025, Low Group
LYU Min
PhD Student, Class of August 2025, Lim Group
HOANG Mai Thanh Truc
PhD Student, Class of August 2025, Yu Group
Hannah Abilaguyo YUSON
PhD Student, Class of August 2025, Holle Group
Diya NARANG
PhD Student, Class of August 2025, Michelot Group
QUAN Cheng
PhD Student, Class of August 2025, Li Group
CHEAM Mei Shan
PhD Student, Class of August 2025, Toyama Group
Thanks to Christiani Amorim at UC Louvain, for the kind invitation
Looking forward to new collaborations in the future!
Congratulations to Wee Juin Shin for being selected to present his work at the Amgen Scholars Asia Symposium!
Our Amgen scholar, Wee Juin Shin, has been selected to present his work on ‘the Influence of substrate curvature on theca cell nematic flow’, at the Amgen Scholar Asia Symposium in Kyoto!
Geetika Chouhan
Research Fellow, Dye Group
Seeking Research Assistant for project with MBI Fellow Dr. Tee Yee Han at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Research Assistant to work with MBI Fellow Dr. Tee Yee Han.
Seeking Research Fellow in the group of Prof. Alexander Bershadsky at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Research Fellow in the group of Prof. Alexander Bershadsky at the MBI, NUS.
