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Bridging the (BP)GAP in metastasis

A collaborative study between researchers at MBI and scientists locally and overseas discovered how a scaffolding protein synchronizes, in space and time, two important regulatory proteins driving cell migration

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Recent Featured Research

A Nervous Contraction

By Shu Chian Tay|Apr 18th, 2022|Categories: Featured Research, Saunders Lab, Science Features|

A collaborative study from the Saunders Lab and the Martin-Blanco Lab at the Molecular Biology Institute Barcelona, Spain, demonstrates how the contraction of a Drosophila's ventral nerve cord during development is oscillatory and driven by the combined contractile efforts of individual cells. Learn more

MBInsights Annual

MBInsights: Decoding the Living Machine

An annual summary of research at the Mechanobiology Institute, National University of Singapore

The annual is a synopsis showing the breadth of the research coming from the MBI. We are very proud of the fact that we have been able to build an institute with state-of-the-art capabilities in super-resolution microscopy and microfabrication. Our open lab environment and the energy of our students and postdocs have combined to take advantage of our experimental tools to answer important biological questions. Because we believe that these tools should be utilized to solve many more problems in the biomedical sciences, we invite you and your colleagues to join us in collaborative studies to solve those problems. Many different disciplines are needed since the problems need the tools of physicists, biologists, computational scientists, and engineers, working side-by-side to better understand how biological systems integrate mechanical cues and physical forces from the world around them.

Read more about MBInsights Annual 2017
See all editions of MBInsights Annual

Awards and Honors

MBI acknowledges our celebrated principal investigators and researchers.

News and Featured Events

Upcoming events, conferences, outreach and more at MBI.

Avery Sun selected for CEMB Future Leaders in Mechanobiology Seminar Series

MBI PhD student Avery Sun was selected for the Future Leaders in Mechanobiology Seminar Series in February 2025. This monthly seminar series is hosted by the Center for Engineering Mechanobiology, University of Pennsylvania, USA.

By Andrew Wong|Mar 5th, 2025|Categories: News|Comments Off on Avery Sun selected for CEMB Future Leaders in Mechanobiology Seminar Series

Collaborators and Visiting Scientists

Visiting faculty, on-site guests and visitors.

MBI Publications

Latest Publications

  1. Ong HT, Sriram M, Susapto HH, Li Y, Jiang Y, Voelcker NH, Young JL, Holle AW, and Elnathan R. The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing. Adv Mater 2025;:e2501640. [PMID: 40576525]
  2. Lee Y, Shen X, Dreesen O, Zhua J, and Li R. Dysregulation of Extracellular Fibronectin and 5-integrin in Dermal Aging. Mol Biol Cell 2025;:mbcE25020074. [PMID: 40560397]
  3. Kumari A, Kumar A, Xu G, Roy K, Pratap R, Holle A, and Tijore A. Confinement Suppresses Mechanical Force-Mediated Cancer Cell Apoptosis. Small 2025;:e2504261. [PMID: 40556557]
  4. Zhang X, Bai J, Fan S, Liang L, Song X, Nai MH, Zhang R, Chen M, Wang J, and Lim CT. Dissecting Exosomal-Tumoral-Vascular Interactions of Single Tumor Cells and Clusters Using a Tumoral-Transendothelial Migration Chip. ACS Nano 2025;. [PMID: 40556461]
  5. Wang J, Qin Y, Wu Q, Zeng D, Gao X, Wang Q, Li Z, Ni Y, Li H, Zhang P, Guo J, Ma W, Maitusun M, Jin X, Chen M, Zhu L, Lu Q, Chen Q, Wu Y, Lin C, Han R, Cheng D, Ni J, Wang X, Yao F, Zhuang J, Xia J, Liu D, Lu Y, Kang P, Yu S, Chen A, Zhang Y, Li Q, Ge W, Long X, Jiang Z, Guan Z, Jin Z, Jin P, Li T, Shu J, Yang J, Wang J, Jiang N, Qian J, Jung Y, Zhang H, Yang Q, Ma L, Wu X, Huang X, Si D, Ren J, Qiao H, Guo Y, Huang Z, Wang W, Deng W, Bi L, Zhao D, Li Y, Lau RWH, Tham Y, Ma X, Ma J, Shen D, Zhang S, Guan H, Zou W, Guo M, Guan X, Yang X, Xu A, Wu J, Panagiotou G, Tse MA, Kim J, Wu E, Thalmann D, Thalmann NM, Fregni F, Wong TY, Jia W, Zeng R, Lim CT, Sheng B, and Li H. An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial. Nat Med 2025;. [PMID: 40551019]
  6. Tsikolia N, Nguyen DTL, and Tee YH. Mechanisms of left-right symmetry breaking across scales. Curr Opin Cell Biol 2025; 95:102564. [PMID: 40544609]
  7. Chang Y, Lee JWN, and Holle AW. The mechanobiology of fibroblast activation in disease. APL Bioeng 2025; 9(2):021505. [PMID: 40538750]
  8. Miotti P, Scarpone M, Lim CT, and Pivkin IV. A Computationally Efficient Viscoelastic Eukaryotic Cell Model. Ann Biomed Eng 2025;. [PMID: 40537593]
  9. Wang C, Shirzaei Sani E, Shih C, Lim CT, Wang J, Armstrong DG, and Gao W. Wound management materials and technologies from bench to bedside and beyond. Nat Rev Mater 2024; 9(8):550-566. [PMID: 40535534]
  10. Li X, Wan S, Pronay TS, Yang X, Gao B, and Lim CT. Toward next-generation smart medical care wearables: where microfluidics meet microneedles. Nanoscale Horiz 2025;. [PMID: 40521959]

All MBI publications

Biomaterial shows how ageing in the heart could be reversed

A new lab-grown material has revealed that some of the effects of ageing in the heart may be slowed and even reversed. The discovery could open the door to therapies that rejuvenate the heart by changing its cellular environment, rather than focusing on the heart cells themselves.Learn more

By Lucie Kim|Jun 18th, 2025|Categories: Science Features|Comments Off on Biomaterial shows how ageing in the heart could be reversed

Rejuvenation of aged egg cells

MBI researchers collaborated with NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality, based at the NUS Yong Loo Lin School of Medicine, to develop an innovative technique to significantly enhance the reproductive potential of aged oocytes, or immature egg cells, potentially paving the way for better outcomes of assisted reproductive technologies, such as in-vitro fertilisation (IVF), for older females. Learn more

By Andrew Wong|Jun 9th, 2025|Categories: Science Features|Comments Off on Rejuvenation of aged egg cells

Microtubules and Cell Movement: A Closer Look at Focal Adhesion Disassembly

Researchers from the Bershadsky Lab at MBI utilized optogenetics to unlock the role of microtubules in regulating focal adhesion disassembly, an important step in cell migration. http://www.mbi.nus.edu.sg/featured-research/microtubules-and-cell-movement-a-closer-look-at-focal-adhesion-disassembly

By Andrew Wong|Oct 30th, 2024|Categories: Featured Research|Comments Off on Microtubules and Cell Movement: A Closer Look at Focal Adhesion Disassembly

Defining the pattern of cell death and replacement

Researchers from the Toyama Lab at MBI reveal how mechanical factors control apoptosis and cell replacement. https://www.mbi.nus.edu.sg/featured-research/defining-the-pattern-of-cell-death-and-replacement

By Andrew Wong|Oct 29th, 2024|Categories: Featured Research|Comments Off on Defining the pattern of cell death and replacement

Contributions

MBInsights is created and curated by the MBI Science Communications Unit. The Science Communications Unit works towards enhancing awareness of progress made in the field of mechanobiology to the general public, science enthusiasts, young students and scientists working in alternative fields. This is achieved by promoting the latest findings in our own research, and in the field in general, through the media, the production of online educational resources, and outreach events.

Have a question or comment about MBI’s research? Contact us.

About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
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