Ariell SMITH

Research Fellow, Mechanobiology Institute, National University of Singapore

asmith85@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Ariell Smith

Research Fellow

Principal Investigator

Jennifer Young

Research Interests

Fabrication of young to aged cardiac model ECM; Cell-matrix interaction; Cell mechanics

Qualifications

Bioengineering B.S, Materials and Biomaterials Science and Engineering M.Sc. &, PhD

Biography

Ariell completed her B.S. (2016-2020), M.Sc., and Ph.D. (2020-2025) at the University of California, Merced. In Prof. Roberto Andresen Eguiluz’s lab at UC Merced, her doctoral work focused on fabrication and characterization of elastic and viscoelastic model extracellular matrices (ECM) and its effects on Human adenocarcinoma lung epithelial cells (A549).

Technical Skills

  • Cell Culture
  • Fabrication of biomaterial (PDMS and PAH)
  • Characterization of biomaterial (microindentation, rheology, tensile testing, and nanoindentation)
  • Microscopy
  • iPSC differentiation (cardiomyocytes)

Selected Publications

  1. Smith, A.M., Pardi, B.,Sousa, I., Gopinath, A., Andresen Eguiluz, R. C., bioRxiv, 2026.02.04.703912. doi.org/10.64898/2026.02.04.703912
  2. Hatano, R., Smith, A. M., Raman, R., Zamora, J. E., Bashir, R., & McCloskey, K. E. (2024). Comparing fabrication techniques for engineered cardiac tissue. Journal of biomedical materials research. Part A, 112(11), 1921–1929. doi.org/10.1002/jbm.a.37737
  3. Smith, A. M., Inocencio, D. G., Pardi, B. M., Gopinath, A., Carlos, R., Eguiluz, A. Facile Determination of the Poisson’s Ratio and Young’s Modulus of Polyacrylamide Gels and Polydimethylsiloxane. ACS Appl. Polym. Mater 2024. doi.org/10.1021/acsapm.3c03154
  4. Gaspar-Morales, E. A., Waterston, A., Sadqi, M. Diaz-Parga, P., Smith, A. M., Gopinath, A., Andresen Eguiluz, R. C., de Alba, E. Natural and Engineered Isoforms of the Inflammasome Adaptor ASC Form Noncovalent, PH-Responsive Hydrogels. Biomacromolecules 2023. 11, 12. doi.org/10.1021/acs.biomac.3c00409
  5. Mann A.S., Smith A.M., Saltzherr J.O., Gopinath A., Andresen Eguiluz, R.C.. Glycosaminoglycans and glycoproteins influence the elastic response of synovial fluid nanofilms on model oxide surfaces. Colloids Surf B Biointerfaces. 2022 May;213:112407. doi.org/10.1016/j.colsurfb.2022.112407. Epub 2022 Feb 10. PMID: 35180655.