Dr Rishita Changede of the Sheetz Lab is exploring how the spacing between matrix protein fibers affect clustering of the cell surface receptors integrins and how this influences the formation of integrin-mediated cell-matrix adhesions and subsequent cell spreading. Learn more
How cells generate high forces for testing the softness of their environment
How phosphoinositides regulate ATR recruitment
HER2 activates mechanosensing on rigid matrices
How FHL2 translocates to the nucleus under low tension
Receptor Tyrosince Kinases control mechanosensors
How talin structure makes it an ideal force buffer
A method to monitor dynamic protein binding at subsecond timescales
Integrin clusters are the universal units of cell adhesion
Cyclic stretching helps soft tissues spread and grow
The field of mechanobiology has grown dramatically in the past decade. With this growth came ground breaking experiments, and findings that challenged the foundations of cell biology.
A leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.
One of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.