Professor Yan Jie and his team from the Mechanobiology Institute collaborated with Professor Liu Xiaogang from the Department of Chemistry, NUS, to determine the exact force needed to activate Piezo1, via a DNA-based approach.
MBI scientists demonstrate how the phenomenon of force-induced stabilization of biomolecular complexes can be explained on a one-dimensional energy landscape by incorporating defined transition coordinates.
Modelling mechanosense and response
Mechanical and biochemical regulation of actin filament polymerization
Fast quantification of DNA-protein interactions under force and torque constraints
Mechanical regulation of actin polymerization by formins
Research Fellow, Yan Jie Group
How talin structure makes it an ideal force buffer
A gene-silencing nucleoprotein filament formed by H-NS family proteins
α-catenin mediated mechanosensing of cell-cell junctions
A leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.
One of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.