Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
MBI Researchers Identify a Signalling Pathway in Stiff Ovarian Tissue Affecting Egg Maturation
A joint study between the Li and Young Labs at MBI, together with A*STAR's Institute of Molecular and Cell Biology, pinpoints the molecular switch responsible for matrix stiffness in ageing ovaries, offering an alternative way to treat age-related infertility without having to reverse stiffness.
MBI to host EMBO Workshop on Cell and Tissue Mechanics of Aging and Regeneration
Organised and hosted by MBI, this EMBO Workshop will be held on 21-24 September 2027 at the Shaw Foundation Alumni House, NUS. Please click on the link to register your interest: https://coming-soon.embo.org/gw27-14
Xiangfu Guo
Research Fellow, Yan Jie Group
Chu Đặng Khánh Hoà
Research Assistant, Dye & Michelot Groups
Koya Yoshizawa
Research Fellow, Zhu Group
Chan lab members present their latest research at the International Conference on Mechanics in Medicine and Biology, Singapore!
Congratulations to Kosei for winning Best Oral Presentation, and to Kelly and Neha for their Poster Prize Awards!
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Seeking Postdoctoral Research Fellow in the research group of Dr. Tsuyoshi Hirashima at the Mechanobiology Institute, NUS ( Cloned )
We are seeking to recruit a Postdoctoral Research Fellow in the Collective Cell Dynamics in Mammalian Development and Reproduction Laboratory at the Mechanobiology Institute, NUS.
MBI Researchers Identify a Signalling Pathway in Stiff Ovarian Tissue Affecting Egg Maturation
A joint study between the Li and Young Labs at MBI, together with A*STAR's Institute of Molecular and Cell Biology, pinpoints the molecular switch responsible for matrix stiffness in ageing ovaries, offering an alternative way to treat age-related infertility without having to reverse stiffness.
MBI to host EMBO Workshop on Cell and Tissue Mechanics of Aging and Regeneration
Organised and hosted by MBI, this EMBO Workshop will be held on 21-24 September 2027 at the Shaw Foundation Alumni House, NUS. Please click on the link to register your interest: https://coming-soon.embo.org/gw27-14
Seeking Research Fellow in Cardiac Organoids and Microphysiological Systems at the Mechanobiology Institute, NUS
The laboratory of Prof. Hanry Yu seeks to to recruit a Research Fellow in Cardiac Organoids and Microphysiological Systems at the Mechanobiology Institute, NUS.
Xiangfu Guo
Research Fellow, Yan Jie Group
Chu Đặng Khánh Hoà
Research Assistant, Dye & Michelot Groups
Seeking Postdoctoral Fellow in the Chan Laboratory at the Mechanobiology Institute, NUS
Asst. Prof. Chan seeks to to recruit a Postdoctoral Fellow in the Chan Laboratory at the Mechanobiology Institute, NUS.
Koya Yoshizawa
Research Fellow, Zhu Group
Seeking Communications & Events Associate at the Mechanobiology Institute, National University of Singapore
The Mechanobiology Institute (MBI), National University of Singapore (NUS), is seeking to recruit a Communications & Events Associate.
Chan lab members present their latest research at the International Conference on Mechanics in Medicine and Biology, Singapore!
Congratulations to Kosei for winning Best Oral Presentation, and to Kelly and Neha for their Poster Prize Awards!
WANG Tiantian
PhD Student, Class of August 2026, Yu Group
Sudha MERLA
PhD Student, Class of August 2026, Toyama Group
