TEE Yee Han
MBI Fellow, Mechanobiology Institute, National University of Singapore
mbityh@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
MBI’s International Conference on Genomes and AI: From Packing to Regulation, October 2-4
MBI's upcoming conference will bring together leading international experts, early-career scientists and students at the intersection of genome biology and machine learning to spur new collaborations across disciplinary boundaries. This is critical for uncovering the mechanogenomic codes that link genome architecture, regulation and function, and ultimately for the development of new biomarkers and therapeutic interventions. The International Conference on Genomes and AI: From Packing to Regulation will cover the following three major themes: 1) Single-cell 1D and 3D Genomics: Experiments and Modeling, 2) Networks: From Expression to Regulatory Modules, and 3) Genome Architecture: Regulation and Biomarkers
MBI welcomes its incoming class of 2019
Congratulations to our incoming students! We're proud to introduce (l to r): Liang Lanfeng, Yan Wu, Kashish Jain, Ignacius Tay Yan Yun, Hu Jinrong, Liu Jingzhun, Leong Kim Whye and Deepika Singh, the newest additions to the MBI community.
Molecular controllers of stem cell mechanics
Recent study led by MBI graduate student Shumin Xia and Principal Investigator Associate Professor Pakorn Tony Kanchanawong use super resolution imaging techniques to study the nanoscale organization of the cortical actin cytoskeleton in mouse embryonic stem cells and understand the role of molecules such as Arp2/3, formins, and capping protein in coordinating cortical architecture in mESCs.
Wu Yan
PhD Student, Class of August 2019, Low Group
Tee Yee Han
MBI Fellow
Principal Investigator
Research Interests
Recent Publications
- Naripogu KB, Tee YH, Senju Y, Bershadsky A, and Robinson RC. Localization of Asgard archaeal ESCRT proteins to eukaryotic cellular structures. Biochem Biophys Res Commun 2026; 802:153301. [PMID: 41576632]
- Tsikolia N, Nguyen DTL, and Tee YH. Mechanisms of left-right symmetry breaking across scales. Curr Opin Cell Biol 2025; 95:102564. [PMID: 40544609]
- Glazenburg MM, Hettema NM, Laan L, Remy O, Laloux G, Brunet T, Chen X, Tee YH, Wen W, Rizvi MS, Jolly MK, and Riddell M. Perspectives on polarity - exploring biological asymmetry across scales. J Cell Sci 2024; 137(5). [PMID: 38441500]
- Tee YH, Goh WJ, Yong X, Ong HT, Hu J, Tay IYY, Shi S, Jalal S, Barnett SFH, Kanchanawong P, Huang W, Yan J, Lim YAB, Thiagarajan V, Mogilner A, and Bershadsky AD. Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives. Nat Commun 2023; 14(1):776. [PMID: 36774346]
- Efremov AK, Yao M, Sun Y, Tee YH, Sheetz MP, Bershadsky AD, Martinac B, and Yan J. Application of piconewton forces to individual filopodia reveals mechanosensory role of L-type Ca2+ channels. Biomaterials 2022; 284:121477. [PMID: 35395455]
- Jalal S, Shi S, Acharya V, Huang RY, Viasnoff V, Bershadsky A, and Tee YH. Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement. J. Cell. Sci. 2019;. [PMID: 30787030]
- Lou Y, Toh TC, Tee YH, and Yu H. 25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells. Sci Rep 2017; 7:42816. [PMID: 28211493]
- Hu S, Dasbiswas K, Guo Z, Tee Y, Thiagarajan V, Hersen P, Chew T, Safran SA, Zaidel-Bar R, and Bershadsky AD. Long-range self-organization of cytoskeletal myosin II filament stacks. Nat. Cell Biol. 2017;. [PMID: 28114270]
- Tee YH, and Bershadsky AD. Actin Retrograde Flow in Permeabilized Cells: Myosin-II Driven Centripetal Movement of Transverse Arcs. Bio Protoc 2016; 6(5):e1743. [PMID: 40656211]
- Hu S, Tee Y, Kabla A, Zaidel-Bar R, Bershadsky A, and Hersen P. Structured illumination microscopy reveals focal adhesions are composed of linear subunits. Cytoskeleton (Hoboken) 2015; 72(5):235-45. [PMID: 26012525]
Lab Members
