Ronen ZAIDEL-BAR
Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University, Israel
Laboratory website
Zaidel-Bar Cell Adhesion Lab
Seeking Research Fellow in the group of Prof. Alexander Bershadsky at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Research Fellow in the group of Prof. Alexander Bershadsky at the MBI, NUS.
Vaishnavi Rangaraj
Research Assistant, Holle Group
Liu Haoqiu
Research Fellow, Michelot Group
Seeking Postdoctoral Research Fellow for collaborative project between Dr. Yin Loon Lee and Prof. Alexander Bershadsky at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Postdoctoral Research Fellow for a collaborative project between Dr. Yin Loon Lee (A*STAR) and Prof. Alexander Bershadsky.
Seeking Postdoctoral Research Fellow in the group of Asst. Prof. Jennifer Young at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Postdoctoral Research Fellow to Asst. Prof. Jennifer Young's lab.
Super excited about the arrival of our optical coherence microscopy! Stay tuned for exciting data in the near future…
A huge thanks to Ling Wang from the Prevedel lab (EMBL Heidelberg) for helping us to set up this device!
Ronen Zaidel-Bar
Visiting Faculty
Currently Visting
6-12 Nov 2018
Office: T-Lab, Level 5
Research Areas
Cell-cell and cell-matrix adhesion, Regulation of actomyosin contractility and dynamics, C. elegans development, mechanics and molecular mechanisms of morphogenesis
Research Interests
- How do specific cytoskeletal proteins contribute to the organization and function of cell adhesion and actomyosin structures?
- How are signals processed within the “adhesome” and “contractome” to arrive at the appropriate cytoskeletal arrangement for a given cell state?
- How do adhesion sites and the cytoskeleton sense and respond to external mechanical forces?
Biography
Dr Zaidel-Bar obtained his Ph.D. working with Prof Benny Geiger (Weizmann Institute of Science) on the role of force in regulating cell-matrix adhesions. Their work first focused on single proteins and evolved to encompass the entire adhesome network. In his Postdoctoral training with Prof Jeff Hardin (University of Wisconsin – Madison) Dr Zaidel-Bar switched from studying cells in culture to employing the genetic model organism C. elegans for the study of cell-cell adhesions during development. Dr Zaidel-Bar was attracted to Singapore by the opening of MBI and was awarded the Singapore National Research Foundation Fellowship for promising young investigators.
Education
PhD Weizmann Institute of Science
Recent Publications
- Bertocchi C, Alegría JJ, Vásquez-Sepúlveda S, Ibanez-Prat R, Srinivasan A, Arrano-Valenzuela I, Castro-Pereira B, Soto-Montandon C, Trujillo-Espergel A, Montenegro-Rojas I, Deguchi S, Owen GI, Kanchanawong P, Cerda M, Motta G, Zaidel-Bar R, and Ravasio A. Systematic AI-assisted screening of the cadhesome to map epithelial monolayer mechanics. Cell Commun Signal 2026;. [PMID: 42399739]
- Ray S, Agarwal P, Nitzan A, Nédélec F, and Zaidel-Bar R. Actin capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans. Development 2023;. [PMID: 36897576]
- Avivi Kela S, Sethi K, Tan PY, Suresh D, Ong HT, Castaneda PG, Amin MR, Laviv T, Cram EJ, Faix J, and Zaidel-Bar R. Tension-dependent RHGF-1 recruitment to stress fibers drives robust spermathecal tissue contraction. J Cell Biol 2022; 222(2). [PMID: 36574264]
- Chen Z, Oh D, Biswas KH, Zaidel-Bar R, and Groves JT. Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. Elife 2021; 10. [PMID: 34414885]
- Hu S, Grobe H, Guo Z, Wang Y, Doss BL, Pan M, Ladoux B, Bershadsky AD, and Zaidel-Bar R. Reciprocal regulation of actomyosin organization and contractility in non-muscle cells by tropomyosins and alpha-actinins. Mol. Biol. Cell 2019;:mbcE19020082. [PMID: 31216217]
- Desai SK, Padmanabhan A, Harshe S, Zaidel-Bar R, and Kenney LJ. Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2019;. [PMID: 31160462]
- Bouffard J, Cecchetelli AD, Clifford C, Sethi K, Zaidel-Bar R, and Cram EJ. The RhoGAP SPV-1 regulates calcium signaling to control the contractility of the C. elegans spermatheca during embryo transits. Mol. Biol. Cell 2019;:mbcE18100633. [PMID: 30726159]
- Priti A, Ong HT, Toyama Y, Padmanabhan A, Dasgupta S, Krajnc M, and Zaidel-Bar R. Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset. Nat Commun 2018; 9(1):4694. [PMID: 30410005]
- Agarwal P, and Zaidel-Bar R. Principles of Actomyosin Regulation In Vivo. Trends Cell Biol. 2018;. [PMID: 30385150]
- Chen Z, Oh D, Biswas KH, Yu C, Zaidel-Bar R, and Groves JT. Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29866846]
Lab Members
Actin Crosslinking
Actin Crosslinking Crosslinking of actin filaments is a critical step in cell motility and is a fundamental process in filopodia protrusion and lamellipodia formation. Smaller cross-linking proteins that are more globular (e.g. fascin) [...]
Alpha-actinin
Alpha-actinin α-actinin is an actin-binding protein [1] and component of the actin crosslinking functional modules; it lacks G-actin binding activity and lacks actin initiation/nucleation activity [2]. α-actinin is an important organizer of the cytoskeleton [...]
Fascin
Fascin Fascin is the major actin crosslinking protein found in a wide range of filopodia [1][2][3]. This protein has been shown to work in concert with other cross linkers such as α-actinin to produce [...]
Fimbrin
Fimbrin Fimbrin (aka plastin homologue, accumentin) is an actin binding protein that was originally identified in microvilli [1][2]. This schematic diagram illustrates the molecular organization of fimbrin as depicted in this resource, and [...]
I-BAR and Other Proteins/Factors
I-BAR and Other Proteins/Factors Proteins containing I-BAR (inverted Bin/amphiphysin/Rvs i.e. IRSp53 Missing-in-metastasis homology Domain or IMD) cooperate with various components of actin filament assembly, to promote filopodia protrusion, via several mechanisms including the stimulation [...]
What is capping protein?
What is capping protein? Capping protein is involved in actin filament assembly and disassembly Capping proteins control access to the free barbed ends of actin filaments and is therefore a major factor affecting actin [...]
What are intermediate filaments?
What are intermediate filaments? Intermediate filaments are a primary component of the cytoskeleton, although they are not found in all eukaryotes, and are absent in fungi and plants [1]. These filaments, which extend throughout [...]
How are intermediate filaments assembled?
How are intermediate filaments assembled? The soluble subunit for creating intermediate filaments is a tetramer. The tetramer is created from monomers in a stepwise fashion (as reviewed in [1]). First, two monomers associate via [...]
What are microtubules?
What are microtubules? Microtubules are hollow cylinders [1] that are approximately 25nm in diameter [2] and vary in length from 200 nm to 25 μm. They are formed by the lateral association of between [...]
Filamin
Filamin The filamin family of proteins bind to both actin and a number of signaling molecules including Rho GTPases. Evidence for this was shown with the loss of Filamin-A in M2 Melanoma cells, which [...]
What are Blebs?
What are Blebs? Blebs are blister-like protrusions that occur at the cell surface (reviewed in [1]). Blebs form, and function, in a series of defined steps. They typically grow to a length of around [...]
What is microtubule dynamic instability?
What is microtubule dynamic instability? In most cell types, thirteen protofilaments associate laterally to form a microtubule. In a few cases microtubules contain more or fewer protofilaments [1]. Numerous interactions between the subunits give [...]
