Researchers from the Bershadsky Lab at MBI utilized optogenetics to unlock the role of microtubules in regulating focal adhesion disassembly, an important step in cell migration. http://www.mbi.nus.edu.sg/featured-research/microtubules-and-cell-movement-a-closer-look-at-focal-adhesion-disassembly
Researchers from the Toyama Lab at MBI reveal how mechanical factors control apoptosis and cell replacement. https://www.mbi.nus.edu.sg/featured-research/defining-the-pattern-of-cell-death-and-replacement
A collaborative study between researchers at MBI and scientists locally and overseas discovered how a scaffolding protein synchronizes, in space and time, two important regulatory proteins driving cell migration Learn more
An interdisciplinary team from MBI combined imaging, microfabrication, and biology to develop JeWells - an innovative platform for growing and imaging organoids in 3D. Learn more
A collaboration between MBI scientists and clinical researchers revealed how a scaffolding protein integrates biochemical and mechanical signals to control cardiac muscle cell differentiation. Learn more
A study from the Saunders lab uncovers how random cell fusion events during muscle development are regulated at the tissue level to ensure correct patterning of the muscle architecture. Learn more
A collaborative study from the Saunders Lab and the Martin-Blanco Lab at the Molecular Biology Institute Barcelona, Spain, demonstrates how the contraction of a Drosophila's ventral nerve cord during development is oscillatory and driven by the combined contractile efforts of individual cells. Learn more
A collaborative study from the Saunders Lab and the Telley Lab at Instituto Gulbenkian de Ciência, Portugal, demonstrates how mechanical repulsive forces lead to precise arrangement of nuclei during development Learn more
A review from Prof Rong Li and Dr. Jin Zhu outlines the the causes of aneuploidy and how it can affect cell behaviour and function. Learn more
A recent study from the Li Lab at the Mechanobiology Institute, National University of Singapore and Johns Hopkins University, USA has revealed new aspects on the involvement of p53 protein in preventing mistakes in chromosomal segregation. Learn more
A recent study from the Grenci Lab at the Mechanobiology Institute, National University of Singapore has described a new, highly-sensitive IR spectroscopy technique that overcomes the limitations of existing techniques by utilizing optical components that are commonly used in existing visible light imaging techniques. Learn more
A recent study led by Dr. Shaobo Zhang and MBI Principal Investigator Associate Professor Timothy Saunders describes how periodic filopodial retraction caused by the contractile activity of transient Myosin II clusters at the cell leading edge ensures precise matching between primitive heart cells during heart development in Drosophila embryos. Learn more
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One of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.