Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Seeking Research Assistant in the research group of Prof. Rong Li at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS, seeks to recruit a Research Assistant in the research group of Prof. Rong Li.
Check out the lab’s latest publication and preprint!
Access the publication or the preprint here!
Seeking Postdoctoral Research Fellow (Biomaterials and Mechanobiology) in the group of Asst. Prof. Jennifer Young at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS, seeks to recruit a Postdoctoral Research Fellow (Biomaterials and Mechanobiology) in the group of Asst. Prof. Jennifer Young.
Congrats to Kelly and Gefei for passing their Qualifying Exams!
Looking forward to the exciting science ahead!
The Chan Lab is delighted to host visitor Norah Spears from U. Edinburgh!
The scientific exchange was fantastic and we deeply appreciated her sharing her scientific journey. It was both inspiring and humbling for our early career researchers!
She is a Scientist: Confidence Formed by Curiosity Over Time
February 11th celebrates The International Day of Women and Girls in Science to promote full, equal access and participation in STEM fields. MBI talks to two of our posdoctoral research fellows about their career as a woman in science.
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Tumor-on-a-chip Shows How Microenvironment Architecture Affects Liver Cancer Therapies
Researchers from the Pavesi Group at the Mechanobiology Institute, NUS develops in vitro models of liver tumors to study how the presence of vasculature networks affect cancer therapies.
Liu Shutong
Research Assistant, Hirashima Group
Seeking Research Assistant in the Vascular Mechano-medicine Lab of Dr. Shailaja Seetharaman at the Mechanobiology Institute, NUS
We are seeking to recruit a Research Assistant in the research group of Dr. Shailaja Seetharaman at the Mechanobiology Institute and Department of Physiology at the Yong Loo Lin School of Medicine, NUS.
MBI-MPG 2025 Conference: A Time and Space of Learning, Honoring and Inspiration
The MBI-MPG Conference 2025: Mechanobiology in Space and Time featured a vibrant scientific programme, communal experiences in Singapore, and moments of remembrance.
Seeking Postdoctoral Research Fellow in the Vascular Mechano-medicine Lab of Dr. Shailaja Seetharaman at the Mechanobiology Institute, NUS
We are seeking to recruit a Postdoctoral Research Fellow in the research group of Dr. Shailaja Seetharaman at the Mechanobiology Institute and Department of Physiology at the Yong Loo Lin School of Medicine, NUS.
Yiwen Tang
Research Fellow, Chan Group
Early Career Researchers’ Day: A Launchpad for Postdocs and PhD Students
A symposium for postdoctoral researchers and PhD students to present their scientific work, network with peers, and participate in career development.
Less is More: Simplified 3D Nanoscopy via Vortex Interference Widens Access
Researchers from the Kanchanawong Lab at the Mechanobiology Institute, NUS makes cutting-edge 3D nanoscopy more accessible to researchers without elaborate optical engineering.
The Chan Lab at the MBI-MPG Conference 2025!
Congratulations to Kim Whye and Kosei for being selected for talks, and Boon Heng for winning the 'Best Poster' prize! Thanks to all who gave feedback on our work!
Rac-1 Regulated Cadherin Clusters Mark Naive Stem Cells
Researchers from the Kanchanawong Lab at the Mechanobiology Institute, NUS discover a marker of ground-state pluripotent stem cells and what governs it.
Confined Migration Shapes the Bony Fate of Stem Cells
Researchers from the Holle Lab at the Mechanobiology Institute, NUS discover that migration through confined spaces causes lasting nuclear changes in stem cells, biasing them toward bone formation.
P. Shakthi
Research Assistant, Dye & Michelot Groups
