Wu Min Group

Yang YANG

Alumni, Mechanobiology Institute, National University of Singapore

a0095425@u.nus.edu
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

The Nano-Heartbuilder: BNIP-2 Influences Mechanosensing in Cardiomyoblast Differentiation

Researchers from the Low Lab at MBI discover a crucial role for the scaffold protein BNIP-2 in orchestrating focal adhesion dynamics during early heart development, offering new insights into heart regeneration strategies.

By Yee Shu Brenda|Aug 12th, 2025|Categories: Featured Research, Low BC Lab, MBInsights, Science Features|Comments Off on The Nano-Heartbuilder: BNIP-2 Influences Mechanosensing in Cardiomyoblast Differentiation
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Shedding Light on Local Microtubule Regulation of Focal Adhesions

Researchers from the Bershadsky Lab at MBI utilized optogenetics to unlock the role of microtubules in regulating focal adhesion disassembly, an important step in cell migration. http://www.mbi.nus.edu.sg/featured-research/microtubules-and-cell-movement-a-closer-look-at-focal-adhesion-disassembly

By Andrew Wong|Aug 8th, 2025|Categories: Bershadsky Lab, Featured Research, MBInsights, Science Features|Comments Off on Shedding Light on Local Microtubule Regulation of Focal Adhesions
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Yang Yang

Alumni

Principal Investigator

Wu Min

Research Interests

The Cell-Matrix and Cell-Cell Mechanotransduction Group

Recent Publications

  1. Xiong D, Tong C, Fung SYS, McClellan S, Yang Y, Yong J, and Wu M. STIM1 and endoplasmic reticulum-plasma membrane contact sites oscillate independently of calcium-induced calcium release. Open Biol 2026; 16(3). [PMID: 41844235]
  2. De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Grunwald-Grube C, Shao C, Zaia J, Evers W, Pengelley S, Suckau D, Wiechmann A, Resemann A, Jabs W, Beck A, Froehlich JW, Huang C, Li Y, Liu Y, Sun S, Wang Y, Seo Y, An HJ, Reichardt N, Ruiz JE, Archer-Hartmann S, Azadi P, Bell L, Lakos Z, An Y, Cipollo JF, Pucic-Bakovic M, Štambuk J, Lauc G, Li X, Wang PG, Bock A, Hennig R, Rapp E, Creskey M, Cyr TD, Nakano M, Sugiyama T, Leung PA, Link-Lenczowski P, Jaworek J, Yang S, Zhang H, Kelly T, Klapoetke S, Cao R, Kim JY, Lee HK, Lee JY, Yoo JS, Kim S, Suh S, de Haan N, Falck D, Lageveen-Kammeijer GSM, Wuhrer M, Emery RJ, Kozak RP, Liew LP, Royle L, Urbanowicz PA, Packer NH, Song X, Everest-Dass A, Lattová E, Cajic S, Alagesan K, Kolarich D, Kasali T, Lindo V, Chen Y, Goswami K, Gau B, Amunugama R, Jones R, Stroop CJM, Kato K, Yagi H, Kondo S, Yuen CT, Harazono A, Shi X, Magnelli PE, Kasper BT, Mahal L, Harvey DJ, O'Flaherty R, Rudd PM, Saldova R, Hecht ES, Muddiman DC, Kang J, Bhoskar P, Menard D, Saati A, Merle C, Mast S, Tep S, Truong J, Nishikaze T, Sekiya S, Shafer A, Funaoka S, Toyoda M, de Vreugd P, Caron C, Pradhan P, Tan NC, Mechref Y, Patil S, Rohrer JS, Chakrabarti R, Dadke D, Lahori M, Zou C, Cairo C, Reiz B, Whittal RM, Lebrilla CB, Wu L, Guttman A, Szigeti M, Kremkow BG, Lee KH, Sihlbom C, Adamczyk B, Jin C, Karlsson NG, Örnros J, Larson G, Nilsson J, Meyer B, Wiegandt A, Komatsu E, Perreault H, Bodnar ED, Said N, Francois Y, Leize-Wagner E, Maier S, Zeck A, Heck AJR, Yang Y, Haselberg R, Yu YQ, Alley W, Leone JW, Yuan H, and Stein SE. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods. Mol Cell Proteomics 2019; 19(1):11-30. [PMID: 31591262]
  3. Chen Y, Yong J, Martínez-Sánchez A, Yang Y, Wu Y, De Camilli P, Fernández-Busnadiego R, and Wu M. Dynamic instability of clathrin assembly provides proofreading control for endocytosis. J. Cell Biol. 2019;. [PMID: 31451612]
  4. Yang Y, and Wu M. Rhythmicity and waves in the cortex of single cells. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2018; 373(1747). [PMID: 29632268]
  5. Yang Y, Xiong D, Pipathsouk A, Weiner OD, and Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev. Cell 2017; 43(4):507-521.e4. [PMID: 29161594]
  6. Xiao S, Tong C, Yang Y, and Wu M. Mitotic Cortical Waves Predict Future Division Sites by Encoding Positional and Size Information. Dev. Cell 2017; 43(4):493-506.e3. [PMID: 29161593]

By Management|2018-03-21T09:53:35+08:00Apr 19th, 2017|Categories: Alumni|Comments Off on Yang Yang

MBI

Decoding the living machine

At the Mechanobiology Institute, National University of Singapore, our goal is to develop the world’s leading centre for mechanobiology research and education. Our research aims to interrogate biological systems from a physical and mechanical perspective at the molecular, cellular, and tissue level, with the eventual goal to leverage basic science discoveries in mechanobiology into biomedical innovations.

MBI gratefully acknowledges support from:

National University of Singapore

National Research Foundation Singapore

Ministry of Education Singapore

Contact us

Mechanobiology Institute (MBI)

National University of Singapore
    T-Lab, #10-01
    5A Engineering Drive 1
    Singapore 117411

Campus map

  mbi.nus.edu.sg
  mbi@nus.edu.sg
  +65 6601 5424

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About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
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