MBI Research Associate Visalatchi Thiagarajan chosen one of Singapore’s top ten techs
MBI Research Associate Visalatchi Thiagarajan has been chosen as one of the top ten laboratory technicians in Singapore, in the inaugural Lab Tech of the Year 2019 awards given out by Asian Scientist Magazine.
Somsubhro Mukherjee
Alumni, Low Group
Dr Hu Xian Edna visiting from University of Oslo
Dr Hu Xian Edna from University of Oslo is visiting from 25 Mar - 23 Apr 2019.
Prof GV Shivashankar featured on Becoming Human, Channel News Asia
MBI Principal Investigator and Deputy Director Professor GV Shivashankar is featured in the Channel News Asia documentary series, Becoming Human: Unnatural Genius to discuss how his lab uses AI and and nuclear mechanogenomic architecture to detect early stage cancer cells.
Le Shimin
Principal Investigator
Research Interests
Molecular Mechanisms of Mechanobiology
My current research has been focused on the molecular mechanics of cell mechanotransduction studied at a single-molecule level, which forms the foundation to understand the cell migration, tissue formation and maintenance, and the mechanobiology-associated translational biomedical applications.
- Single-molecule mechanobiology and biophysics at cell-ECM adhesion and cell-cell junctions;
- Single-molecule mechanobiology and biophysics at nuclear-cytoskeletal linkages and cell cytoskeleton;
- Biophysical studies of gene regulations, DNA replication and repairs by various single-DNA manipulation assays.
Recent Publications
- Ball NJ, Turkki P, Guo Y, Tanvir MH, Le S, Chin JFL, Baker KB, Luo J, Atherton P, Brown NH, Hytönen VP, Yan J, and Goult BT. An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics. Proc Natl Acad Sci U S A 2026; 123(45):e2602326123. [PMID: 42981030]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Le S, Yu M, Fu C, Heier JA, Martin S, Hardin J, and Yan J. Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction. Proc Natl Acad Sci U S A 2024; 121(37):e2400654121. [PMID: 39236238]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Sun Y, Liu X, Huang W, Le S, and Yan J. Structural domain in the Titin N2B-us region binds to FHL2 in a force-activation dependent manner. Nat Commun 2024; 15(1):4496. [PMID: 38802383]
- Huang W, Liu J, Le S, Yao M, Shi Y, and Yan J. In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein. APL Bioeng 2024; 8(1):016114. [PMID: 38435467]
- Zhou Y, Zhao X, Jiang Y, Lin DJ, Lu C, Wang Y, Le S, Li R, and Yan J. A Mechanical Assay for the Quantification of Anti-RBD IgG Levels in Finger-Prick Whole Blood. ACS Sens 2023;. [PMID: 37582229]
- Liu J, Le S, Yao M, Huang W, Tio Z, Zhou Y, and Yan J. Tension Gauge Tethers as Tension Threshold and Duration Sensors. ACS Sens 2023;. [PMID: 36731861]
- Huang W, Le S, Sun Y, Lin DJ, Yao M, Shi Y, and Yan J. Mechanical Stabilization of a Bacterial Adhesion Complex. J Am Chem Soc 2022;. [PMID: 36070862]
- Wang Y, Yao M, Baker KB, Gough RE, Le S, Goult BT, and Yan J. Force-Dependent Interactions between Talin and Full-Length Vinculin. J Am Chem Soc 2021;. [PMID: 34463480]
Full Publication List
