Anne Beghin
Research Assistant Professor, Facility Manager, Microscopy Core
Signaling in cell fate specifcation
Both when and where matter
MBI 10th Anniversary Celebration: 6-12 NOV 2018
One of five Research Centres of Excellence established by the NRF and MOE, the Mechanobiology Institute, National University of Singapore, was created 10 years ago. This November MBI will celebrate its 10th with the following events: Women in Science Satellite Meeting on the 6th, MBI's 10th Anniversary Conference from the 7th to 11th, and our Graduate Student Congress from the 11th to the 12th.
Taking pole positions
How polarity proteins localize at opposite poles during symmetry breaking
MBI Roadshow in China
The MBI Roadshow in China will take place in Guangzhou at the South China University of Technology, and in Shenzhen at the Southern University of Science & Technology, from 12 to 15 October, 2018.
Mario Adan Mendieta Serrano
Research Fellow, Saunders Group
Jokhun Doorgesh Sharma
Alumni
Whether it was because of my rich ‘scientific’ sachildhood or my unflinching preference for science in high school, I had known for a long time that I was to work in a scientific field. But when I started to apply for undergraduate programs, it was really hard to choose between Life Sciences, Physics or engineering. I eventually ended up doing Life Sciences at the National University of Singapore (NUS); but my soft spot for physical sciences persisted and I registered for quite a few random physics and engineering courses along the way.
My first encounter with formal research was during a summer internship at the Institute of Molecular and Cell Biology (IMCB), A*STAR. Following that I embarked on a one year undergraduate research project at NUS in which I helped set up an autogenic platform for differentiation of human embryonic stem cells (hESCs). I was really fascinated by the whole experience and decided to undertake my Final Year Project in the same lab.
In my final semester, I enrolled for the undergraduate Mechanobiology course (LSM4234) and learned about the MechanoBiology Institute (MBI), where so much exciting biological research is being conducted using truly multi-disciplinary approaches. I was really excited by the prospect of working in Biology while still being in touch with Physics. Thus I joined Prof. Shivashankar’s lab as a Research Assistant in 2013 and after one year, I was very convinced this is where I want to be. The atmosphere is very conducive, members of Shiva’s lab are truly amazing people :-D and I am addressing questions which are intellectually very stimulating to me. Hence in Aug 2014 I joined Prof. Shivashankar’s group under the PhD program in Mechanobiology.
I have been studying how different extracellular matrix (ECM) constraints impinge on the stability of telomeres inside the nucleus. I observed that under certain matrix constraints, the telomeres can become very dynamic. Now I am interested in understanding the mechanism and biological significance of this instability, especially in the context of epigenetic reprogramming. Further, since telomeres are known to be hotspots for DNA damage, I want to study DNA damage and repair on highly dynamic telomeres. One question which has been bothering me for some time now is how most DNA damages (several tens of thousands per cell per day) are properly taken care of by intrinsic mechanisms, whereas once in a while, a cell will acquire damage in an irreparable manner and turn tumorous. Does mechanics play a role in that?
