WANG Yejun
Alumni, Mechanobiology Institute, National University of Singapore
mbiwye@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
Physically rewiring the genome
Researchers turn mature cells into stem cells using mechanical cues alone
Signaling in 3D
MBI Scientists reveal a spatial dimension to cell signaling
Wang Yejun
Alumni
I decided to switch into the world of biology after I received my BS in chemistry from Zhejiang University. With the interest in things happening inside nucleus, I joined Prof. Shiva’s lab as a graduate student, to study the role of external mechanical signals on gene regulation in eukaryotic cells. During my first one and a half years I developed a method to visualize active transcription sites on open chromatin spreads using super-resolution microscopy. Presently I’m studying the role of cell geometric constraints on 3D organization of chromosomes by using multiple techniques such as fluorescence in situ hybridization (FISH), confocal imaging, and super-resolution imaging.
Recent Publications
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Morales-Camilo N, Liu J, Ramírez MJ, Canales-Salgado P, Alegría JJ, Liu X, Ong HT, Barrera NP, Fierro A, Toyama Y, Goult BT, Wang Y, Meng Y, Nishimura R, Fong-Ngern K, Low CSL, Kanchanawong P, Yan J, Ravasio A, and Bertocchi C. Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction. Nat Commun 2024; 15(1):5608. [PMID: 38969637]
- Zhang X, Ruan L, Wang H, Zhu J, Li T, Sun G, Dong Y, Wang Y, Berreby G, Shay A, Chen R, Ramachandran S, Dawson VL, Dawson TM, and Li R. Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity. NPJ Parkinsons Dis 2024; 10(1):120. [PMID: 38906862]
- Wang Y, Ruan L, Zhu J, Zhang X, Chang AC, Tomaszewski A, and Li R. Metabolic regulation of misfolded protein import into mitochondria. Elife 2024; 12. [PMID: 38900507]
- Wang Y, Ruan L, and Li R. GPI-anchored Gas1 protein regulates cytosolic proteostasis in budding yeast. G3 (Bethesda) 2024;. [PMID: 38289859]
- McNamara JT, Zhu J, Wang Y, and Li R. Gene dosage adaptations to mtDNA depletion and mitochondrial protein stress in budding yeast. G3 (Bethesda) 2023;. [PMID: 38126114]
- Zhou Y, Zhao X, Jiang Y, Lin DJ, Lu C, Wang Y, Le S, Li R, and Yan J. A Mechanical Assay for the Quantification of Anti-RBD IgG Levels in Finger-Prick Whole Blood. ACS Sens 2023;. [PMID: 37582229]
- Wang Y, Ruan L, and Li R. GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeast. bioRxiv 2023;. [PMID: 37292646]
- Wang Y, Ruan L, Zhu J, Zhang X, Chih-Chieh Chang A, Tomaszewski A, and Li R. Metabolic regulation of misfolded protein import into mitochondria. bioRxiv 2023;. [PMID: 37034811]
- Sun AR, Sun Q, Wang Y, Hu L, Wu Y, Ma F, Liu J, Pang X, and Tang B. Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation. Biomater Res 2023; 27(1):21. [PMID: 36927570]
