WU Min
Collaborator, Mechanobiology Institute, National University of Singapore
dbswum@nus.edu.sg
+65 6601 2310
CBIS Blk S1A, Level 2 Lee Wee Kheng Bldg
National University of Singapore
14 Science Drive 4
Singapore 117557
Laboratory website
Wu Lab Deconstructing the Endocytic Machinery
Research Program
The Cell-Matrix and Cell-Cell Mechanotransduction Group
Affiliations
Department of Biological Sciences, National University of Singapore
Synchrony of Waves
The collective dynamics of endocytosis
Wu Min
Collaborator
Research Areas
Endocytosis, Membrane traffic, Curvature, Actin cytoskeleton, Mechanotransduction
Research Interests
Dr Wu is interested in elucidating the principles underlying the organization and dynamics of the subcellular membrane compartments. Specifically her lab investigates how biological membranes are shaped through collective protein-lipid interactions and how geometry of the membrane compartment is coupled to cellular functions. The Wu Lab uses a combination of cell biological, biophysical and biochemical approaches to address these questions.
Biography
Dr Wu Min graduated from Peking University in China and received her bachelor degree in Chemistry. She did her graduate studies at Cornell University with Dr Barbara Baird, where she initiated the use of patterned lipid bilayers as antigen-presenting platforms and studied immune cell activation and signal transduction. During her post-doctoral research in the laboratory of Dr Pietro De Camilli at Yale School of Medicine, she focused on the molecular mechanisms of endocytosis. In 2011, she was awarded the NRF fellowship, joining CBIS/MBI in the fall.
Education
PhD Cornell University
Recent Publications
- Xiong D, Tong C, Fung SYS, McClellan S, Yang Y, Yong J, and Wu M. STIM1 and endoplasmic reticulum-plasma membrane contact sites oscillate independently of calcium-induced calcium release. Open Biol 2026; 16(3). [PMID: 41844235]
- Chua XL, Tong CS, Su M, Xǔ XJ, Xiao S, Wu X, and Wu M. Competition and synergy of Arp2/3 and formins in nucleating actin waves. Cell Rep 2024; 43(7):114423. [PMID: 38968072]
- Tong CS, Su M, Sun H, Chua XL, Xiong D, Guo S, Raj R, Ong NWP, Lee AG, Miao Y, and Wu M. Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1. Front Cell Dev Biol 2024; 11:1261117. [PMID: 38567385]
- Le Chua X, Tong CS, Xǔ XJ, Su M, Xiao S, Wu X, and Wu M. Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves. bioRxiv 2023;. [PMID: 37745345]
- Su M, Zhuang Y, Miao X, Zeng Y, Gao W, Zhao W, and Wu M. Comparative Study of Curvature Sensing Mediated by F-BAR and an Intrinsically Disordered Region of FBP17. iScience 2020; 23(11):101712. [PMID: 33205024]
- Chen Y, Yong J, Martínez-Sánchez A, Yang Y, Wu Y, De Camilli P, Fernández-Busnadiego R, and Wu M. Dynamic instability of clathrin assembly provides proofreading control for endocytosis. J. Cell Biol. 2019;. [PMID: 31451612]
- . https://www.ncbi.nlm.nih.gov/pubmed/31390543
- Yong J, Chen Y, and Wu M. Real-Time Monitoring of Clathrin Assembly Kinetics in a Reconstituted System. Methods Mol. Biol. 2018; 1847:177-187. [PMID: 30129017]
- Yang Y, and Wu M. Rhythmicity and waves in the cortex of single cells. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2018; 373(1747). [PMID: 29632268]
- McPherson PS, and Wu M. Light, space, and time in cancer signaling. Mol. Biol. Cell 2018; 29(6):688. [PMID: 29535172]
Lab Members
Force sensing in cells at the single molecule level
Professor Yan Jie and his team from the Mechanobiology Institute collaborated with Professor Liu Xiaogang from the Department of Chemistry, NUS, to determine the exact force needed to activate Piezo1, via a DNA-based approach.
MBI Hosts Students from Raffles Girls School!
MBI hosted students from Raffles Girls School on 28 April 2026, for an outreach session designed to spark curiosity about mechanobiology and research careers.
Farewell Avery, All the Best!
Farewell to Dr. Avery Rui Sun, a former PhD student at the Young Lab from 2021-2026!
Ting, Hatice and Raageshwari in ASBTE Conference 2026
The Young Lab attends the 2026 Australasian Society for Biomaterials and Tissue Engineering (ASBTE) from 30 Mar-2 Apr 2026!
Pallavi Chinnu Varghese
Research Fellow, Young Group
Takafumi Sakai
Research Fellow, Hirashima Group
Paulina Magdalena Pokorska
Research Fellow, Li Group
Piyush Amitabh
Research Fellow, Dye Group
Katherine Anne Lau Enqi
Research Assistant, Young Group
Zhou Hanzhang
Research Fellow, Yu Group
Dongyu Xu
Research Fellow, Yu Group
Li Guang
Research Fellow, Yu Group
