Saradha VENKATACHALAPATHY
PhD Student, Mechanobiology Institute, National University of Singapore
E0018317@u.nus.edu
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
How do mechanically-gated ion channels facilitate mechanotransduction?
How do mechanically-gated ion channels facilitate mechanotransduction? Mechanotransduction relies on the ability of cells to convert mechanical cues, such as stretch or compression, to biochemical signals. One way this occurs is through the activity [...]
How do lipid bilayer components move?
How do lipid bilayer components move? One of the tenets of the Fluid-Mosaic membrane model is that the components of the bilayers are free to move. Before describing the differences between lipid and protein [...]
Why are membrane lipids asymmetrical?
Why are membrane lipids asymmetrical? The human red blood cell is functionally specialized for transporting oxygen. In order to maximize oxygen capacity, it has no nucleus or organelles, consisting primarily of plasma membrane and [...]
What are cytoskeletal cages?
What are cytoskeletal cages? Cytoskeletal components can assemble into cage-like structures within the cell. These cages serve to segregate intracellular regions or organelles, and can protect their contents from mechanical stress. At the level [...]
What is caveolar endocytosis?
What is caveolar endocytosis? Caveolar endocytosis is a clathrin-independent endocytic process which involves bulb-shaped, 50-60nm plasma membrane invaginations called caveolae (or ‘little caves’). Caveolae formation is driven by integral membrane proteins called caveolins as [...]
What is Membrane Trafficking?
What is Membrane Trafficking? Membrane trafficking encompasses the wide variety of processes that go into the movement of cargo (typically proteins, pathogens and other macromolecules) using membrane bound transport vesicles. This transport can take [...]
Saradha Venkatachalapathy
PhD Student
Recent Publications
- Venkatachalapathy S, Sreekumar D, Ratna P, and Shivashankar GV. Actomyosin contractility as a mechanical checkpoint for cell state transitions. Sci Rep 2022; 12(1):16063. [PMID: 36163393]
- Venkatachalapathy S, Jokhun DS, Andhari M, and Shivashankar GV. Single cell imaging-based chromatin biomarkers for tumor progression. Sci Rep 2021; 11(1):23041. [PMID: 34845273]
- Yang KD, Belyaeva A, Venkatachalapathy S, Damodaran K, Katcoff A, Radhakrishnan A, Shivashankar GV, and Uhler C. Multi-domain translation between single-cell imaging and sequencing data using autoencoders. Nat Commun 2021; 12(1):31. [PMID: 33397893]
- Yang KD, Damodaran K, Venkatachalapathy S, Soylemezoglu AC, Shivashankar GV, and Uhler C. Predicting cell lineages using autoencoders and optimal transport. PLoS Comput. Biol. 2020; 16(4):e1007828. [PMID: 32343706]
- Venkatachalapathy S, Jokhun DS, and Shivashankar GV. Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments. Mol. Biol. Cell 2020;:mbcE19080420. [PMID: 32023167]
- Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan AV, Sharma Jokhun D, Shenoy VB, and Shivashankar GV. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol. Biol. Cell 2018;:mbcE18040256. [PMID: 30256731]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
- Belyaeva A, Venkatachalapathy S, Nagarajan M, Shivashankar GV, and Uhler C. Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 29229825]
- Radhakrishnan AV, Jokhun DS, Venkatachalapathy S, and Shivashankar GV. Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry. Biophys. J. 2017; 112(9):1920-1928. [PMID: 28494962]
- Mitra A, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, and Shivashankar GV. Cell geometry dictates TNFα-induced genome response. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 28461498]
