Bershadsky Group

TEE Yee Han

MBI Fellow, Mechanobiology Institute, National University of Singapore

mbityh@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Force sensing in cells at the single molecule level

Professor Yan Jie and his team from the Mechanobiology Institute collaborated with Professor Liu Xiaogang from the Department of Chemistry, NUS, to determine the exact force needed to activate Piezo1, via a DNA-based approach.

By Yee Shu Brenda|May 5th, 2026|Categories: News, Yan Jie Lab|Comments Off on Force sensing in cells at the single molecule level

MBI Hosts Students from Raffles Girls School!

MBI hosted students from Raffles Girls School on 28 April 2026, for an outreach session designed to spark curiosity about mechanobiology and research careers.

By Yee Shu Brenda|Apr 29th, 2026|Categories: MBInsights, News|Comments Off on MBI Hosts Students from Raffles Girls School!

Tee Yee Han

MBI Fellow

Principal Investigator

Alexander Bershadsky

Research Interests

Cell-Matrix and Cell-Cell Mechanotransduction

Recent Publications

  1. Naripogu KB, Tee YH, Senju Y, Bershadsky A, and Robinson RC. Localization of Asgard archaeal ESCRT proteins to eukaryotic cellular structures. Biochem Biophys Res Commun 2026; 802:153301. [PMID: 41576632]
  2. Tsikolia N, Nguyen DTL, and Tee YH. Mechanisms of left-right symmetry breaking across scales. Curr Opin Cell Biol 2025; 95:102564. [PMID: 40544609]
  3. Glazenburg MM, Hettema NM, Laan L, Remy O, Laloux G, Brunet T, Chen X, Tee YH, Wen W, Rizvi MS, Jolly MK, and Riddell M. Perspectives on polarity - exploring biological asymmetry across scales. J Cell Sci 2024; 137(5). [PMID: 38441500]
  4. Tee YH, Goh WJ, Yong X, Ong HT, Hu J, Tay IYY, Shi S, Jalal S, Barnett SFH, Kanchanawong P, Huang W, Yan J, Lim YAB, Thiagarajan V, Mogilner A, and Bershadsky AD. Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives. Nat Commun 2023; 14(1):776. [PMID: 36774346]
  5. Efremov AK, Yao M, Sun Y, Tee YH, Sheetz MP, Bershadsky AD, Martinac B, and Yan J. Application of piconewton forces to individual filopodia reveals mechanosensory role of L-type Ca2+ channels. Biomaterials 2022; 284:121477. [PMID: 35395455]
  6. Jalal S, Shi S, Acharya V, Huang RY, Viasnoff V, Bershadsky A, and Tee YH. Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement. J. Cell. Sci. 2019;. [PMID: 30787030]
  7. Lou Y, Toh TC, Tee YH, and Yu H. 25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells. Sci Rep 2017; 7:42816. [PMID: 28211493]
  8. Hu S, Dasbiswas K, Guo Z, Tee Y, Thiagarajan V, Hersen P, Chew T, Safran SA, Zaidel-Bar R, and Bershadsky AD. Long-range self-organization of cytoskeletal myosin II filament stacks. Nat. Cell Biol. 2017;. [PMID: 28114270]
  9. Tee YH, and Bershadsky AD. Actin Retrograde Flow in Permeabilized Cells: Myosin-II Driven Centripetal Movement of Transverse Arcs. Bio Protoc 2016; 6(5):e1743. [PMID: 40656211]
  10. Hu S, Tee Y, Kabla A, Zaidel-Bar R, Bershadsky A, and Hersen P. Structured illumination microscopy reveals focal adhesions are composed of linear subunits. Cytoskeleton (Hoboken) 2015; 72(5):235-45. [PMID: 26012525]

Lab Members

By Management|2024-08-07T15:45:20+08:00Apr 10th, 2017|Categories: Bershadsky Lab People, Senior Research Fellow|Comments Off on Tee Yee Han

About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
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