WONG Chen Pei Darren

Senior Research Fellow, Mechanobiology Institute, National University of Singapore

dbsdwcp@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Wong Chen Pei Darren

Senior Research Fellow

Principal Investigator

Low Boon Chuan

Research Interests

The Cell-Matrix and Cell-Cell Mechanotransduction Group

Recent Publications

  1. Xiao J, Ang JW, Zhong X, Wong DCP, T T, Yow I, Lee CJM, Foo RS, Kanchanawong P, and Low BC. Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation. ACS Appl Mater Interfaces 2025;. [PMID: 39778877]
  2. Lee CJM, Autio MI, Zheng WH, Song Y, Wang SC, Wong DCP, Xiao J, Zhu Y, Yusoff P, Yei X, Chock WK, Low BC, Sudol M, and Foo RS. Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage. Circulation 2024;. [PMID: 38752370]
  3. Wong DCP, Pan CQ, Er SY, Thivakar T, Rachel TZY, Seah SH, Chua PJ, Jiang T, Chew TW, Chaudhuri PK, Mukherjee S, Salim A, Aye TA, Koh CG, Lim CT, Tan PH, Bay BH, Ridley AJ, and Low BC. The Scaffold RhoGAP Protein ARHGAP8/ BPGAP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration. Mol Biol Cell 2023;:mbcE21030099. [PMID: 36598812]
  4. Wong DCP, Xiao J, Chew TW, Pan M, Lee CJM, Ang JW, Yow I, Thivakar T, Ackers-Johnson M, Lee NJW, Foo RS, Kanchanawong P, and Low BC. BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation. Adv Sci (Weinh) 2022;:e2202834. [PMID: 35975420]
  5. Wong DCP, Lee EHC, Er J, Yow I, Koean RAG, Ang O, Xiao J, Low BC, and Ding JL. Lung Cancer Induces NK Cell Contractility and Cytotoxicity Through Transcription Factor Nuclear Localization. Front Cell Dev Biol 2022; 10:871326. [PMID: 35652099]
  6. Pan M, Chew TW, Wong DCP, Xiao J, Ong HT, Chin JFL, and Low BC. BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation. Sci Adv 2020; 6(31):eaaz1534. [PMID: 32789168]

Selected Publications

  1. E.H.C. Lee, D.C.P. Wong, J.L. Ding, NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton, Front. Immunol. (2021). https://doi.org/10.3389/fimmu.2021.734551. (Co-first)
  2. D.C.P. Wong, J.L. Ding, The mechanobiology of NK cells- ‘Forcing NK to Sense’ target cells, Biochim. Biophys. Acta – Rev. Cancer. 1878 (2023) 188860. https://doi.org/https://doi.org/10.1016/j.bbcan.2023.188860.
  3. Wong, D. C. P., Xia, Z., Shao, N., Yow, I., Thivakar, T., Yeo, J. Y., Salazar, A. M., Liou, Y.-C., Low, B. C., Ding, J. L., Hiltonol, a dsRNA Mimic, Promotes NK Cell Anticancer Cytotoxicity Through TAZ Cytoplasmic Sequestration. Adv. Therap. 2023, 2300016. https://doi.org/10.1002/adtp.202300016