In a study published in Molecular Biology of the Cell led by Celestine Ho at the Mechanobiology Institute, NUS, researchers discover that HIF-1α-activation in SASP is a defining feature of the SASP induced by diverse stressors, acting independently of micronuclei generation and cGAS/STING activation.
Researchers from the Low Lab at MBI discover a crucial role for the scaffold protein BNIP-2 in orchestrating focal adhesion dynamics during early heart development, offering new insights into heart regeneration strategies.
A collaborative study between researchers at MBI and scientists locally and overseas discovered how a scaffolding protein synchronizes, in space and time, two important regulatory proteins driving cell migration Learn more
A collaboration between MBI scientists and clinical researchers revealed how a scaffolding protein integrates biochemical and mechanical signals to control cardiac muscle cell differentiation. Learn more
Recent study led by MBI Research Fellows Pan Meng and Ti Weng Chew and Principal Investigator Associate Professor Low Boon Chuan has revealed a role for BNIP-2 protein in scaffolding GEF-H1 and RhoA, following microtubule disassembly, and has described how this scaffolding is important for RhoA-dependent regulation of cell migration. Learn more
How cancer cells spread in response to physical cues from their surroundings
To grow or not to grow?
Molecular response to depth sensing differs in cancer cells
Actin remodeling drives bile regurgitation during obstructive cholestasis
MBI Scientists reveal the effects of ECM topography on the poliferation of normal and cancer cells
BNIP-H regulates neurotransmitter Acetylcholine
Clues for targeting Ras-driven liver cancer through RhoA activation
A leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.
One of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.