Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Disrupted Cell-Matrix Interactions Drives Aging and Reveals New Paths for Skin Regeneration
Researchers from the Li Lab discover how α5-integrin–FN interactions preserve dermal integrity, offering new insights for antiaging strategies targeting ECM organization and fibroblast function.
DECIPHERing the Role of Cell-Matrix Interactions in Ageing Heart Health
Researchers from the Soft Nano-Biomaterials Lab at MBI developed a material system to enable precise investigation into how individual ECM properties affect cultured heart cells.
Seeking Postdoctoral Research Fellow in the research group of Dr. Tsuyoshi Hirashima at the Mechanobiology Institute, NUS
We are seeking to recruit a Postdoctoral Research Fellow in the research group of Dr. Tsuyoshi Hirashima at the Mechanobiology Institute, NUS.
How Dying Cells Signal Growth: Mechanical Forces Drive Targeted Cell Proliferation after Apoptosis
Researchers from the Toyama Lab at MBI reveal how mechanical factors control apoptosis and cell replacement.
Scientists Develop AI-Driven Tool to Map 3D Cellular Landscapes
Researchers from the Beghin Lab at the Mechanobiology Institute, NUS combine DeepStar3D algorithm and 3DCellScope interface to develop an experimental tool for real-time interaction with cell data.
Seeking Research Assistant in Transmission Electron Microscopy at the Mechanobiology Institute, NUS
We are seeking a Research Assistant in Transmission Electron Microscopy (TEM) at the Mechanobiology Institute, NUS
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Sriram Muthukumar
Research Fellow, Holle Group
Espérance Nku-Mokabo
Research Associate, Grenci Group
Xiaohong Yao
Research Fellow, Li Group
Seeking Postdoctoral Research Fellow in the research group of Dr. Tsuyoshi Hirashima at the Mechanobiology Institute, NUS
We are seeking to recruit a Postdoctoral Research Fellow in the research group of Dr. Tsuyoshi Hirashima at the Mechanobiology Institute, NUS.
Liu Fan
Senior Research Fellow, Grenci Group
Seeking Postdoctoral Fellow in Dr. Yan Jie’s & Dr. Alexander Ludwig’s group at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Postdoctoral Research Fellow to Dr. Yan Jie and Alexander Ludwig's group.
Seeking Postdoctoral Research Fellow in the Chan Laboratory, Mechanobiology Institute, NUS
We are seeking to recruit a Postdoctoral Research Fellow in the Chan Laboratory at the Mechanobiology Institute, NUS.
Visit from Prof. Raymond Rodgers, a leading expert in mammalian ovarian biology, in January 2024!
The Chan Lab is incredibly grateful to have Ray share his research with us. After enjoying many discussions and fun moments, we look forward to more future collaborations!
Seeking Scientific Communicator at the Mechanobiology Institute, National University of Singapore
The Mechanobiology Institute (MBI), National University of Singapore (NUS), is seeking to recruit a Scientific Communicator.
Congratulations to Jake Turley in securing prestigious Eric & Wendy Schmidt AI in Science Postdoc Fellowship!
Congratulations to Jake Turley in securing prestigious Eric & Wendy Schmidt AI in Science Postdoc Fellowship!
Jake Matthew Turley
Schmidt AI In Science Postdoctoral Fellow, Chan Group
Nicole Ng Shu Ying
Research Assistant, Hirashima Group
