Yusuke HARA
Alumni, Mechanobiology Institute, National University of Singapore
mbiyusu@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
How does nucleation of actin initiate lamellipodia formation?
How does nucleation of actin initiate lamellipodia formation? In the first phase of lamellipodia formation, actin filament polymerization produces a protrusive force on the cell membrane that promotes the spreading out and enlargement of [...]
What mechanisms drive extension, pause and stasis of the lamellipodia?
What mechanisms drive extension, pause and stasis of the lamellipodia? Extension of the newly formed actin filament branches occurs at the interface between the leading edge and the existing actin filament network [1] and [...]
How do focal adhesions act as molecular clutches in lamellipodia?
How do focal adhesions act as molecular clutches in lamellipodia? Once formed, focal adhesions essentially act as “molecular clutches”, promoting protrusion at the leading edge whilst suppressing membrane contraction (reviewed in [1] [2][3]). Adhesions [...]
How does force generation within lamellipodia facilitate cell translocation?
How does force generation within lamellipodia facilitate cell translocation? Interactions between actin filament networks and the focal adhesions to which they are linked results in the generation of forces. These forces may be exerted [...]
What are invadopodia?
What are invadopodia? Invadopodia are actin-rich structures that are present at the basal surfaces of cells that are capable of crossing extracellular barriers, such as cancer cells. The primary function of invadopodia appears to [...]
What mechanisms drive retraction of the trailing edge?
What mechanisms drive retraction of the trailing edge? Protrusion at the front and retraction at the rear are key force-generating processes at the cell periphery that culminate in the translocation of the cell. For [...]
Yusuke Hara
Alumni
Recent Publications
- Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Author Correction: Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2018;. [PMID: 29507405]
- Hara Y. Contraction and elongation: Mechanics underlying cell boundary deformations in epithelial tissue. Dev. Growth Differ. 2017;. [PMID: 28573735]
- Ding WY, Ong HT, Hara Y, Wongsantichon J, Toyama Y, Robinson RC, Nédélec F, and Zaidel-Bar R. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. J. Cell Biol. 2017;. [PMID: 28400443]
- Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2017;. [PMID: 28346438]
- Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege R, and Kanchanawong P. Nanoscale architecture of cadherin-based cell adhesions. Nat. Cell Biol. 2016;. [PMID: 27992406]
- Hara Y, Shagirov M, and Toyama Y. Cell Boundary Elongation by Non-autonomous Contractility in Cell Oscillation. Curr. Biol. 2016; 26(17):2388-96. [PMID: 27524484]
