YU Miao
Research Fellow, Mechanobiology Institute, National University of Singapore
mbiyum@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
MBI hosts Physics Colloquium for Olympiad students
As part of the Physics Colloquium for Olympiad Students program, MBI hosted a group of high school students from different schools across Singapore to learn more about interdisciplinary sciences such as Mechanobiology and to get better insights into the application of physical principles in order to answer complex biological questions.
HER2 can HEAR2
HER2 activates mechanosensing on rigid matrices
Too Deep To Divide!
Molecular response to depth sensing differs in cancer cells
Yu Miao
Research Fellow
Recent Publications
- Huang M, Chen Y, Liang C, Narayan OP, Stallings C, Yu M, Traugot C, Li L, Li K, Vo Q, Wang H, Chou Y, Cech L, Parra D, Garzon L, Parsons D, Diaz E, Zhang C, Mackey C, Sussman H, Zmirska I, Chung M, Zhou C, Glynatsis G, Siemann DW, Licht JD, Li C, Kaye FJ, Xie M, Tan Y, Wu L, Bivona TG, Guan J, and Tang X. Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability. Biomaterials 2025; 329:123920. [PMID: 41443038]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Le S, Yu M, Fu C, Heier JA, Martin S, Hardin J, and Yan J. Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction. Proc Natl Acad Sci U S A 2024; 121(37):e2400654121. [PMID: 39236238]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Yu M, Lu J, Le S, and Yan J. Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature. J Phys Chem Lett 2021;:7914-7920. [PMID: 34384021]
- Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD, Jørgensen C, Humphries MJ, and Goult BT. Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. J Biol Chem 2021;:100837. [PMID: 34118235]
- Yu M, Zhao Z, Chen Z, Le S, and Yan J. Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains. Nat Commun 2020; 11(1):4476. [PMID: 32900995]
- Le S, Yu M, and Yan J. Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin-talin/α-catenin linkages. Sci Adv 2019; 5(12):eaav2720. [PMID: 31897422]
- Le S, Yu M, Bershadsky A, and Yan J. Mechanical regulation of formin-dependent actin polymerization. Semin. Cell Dev. Biol. 2019;. [PMID: 31813767]
- Le S, Yu M, and Yan J. Phosphorylation Reduces the Mechanical Stability of the α-Catenin/ β-Catenin Complex. Angew. Chem. Int. Ed. Engl. 2019;. [PMID: 31625226]
