YU Miao
Research Fellow, Mechanobiology Institute, National University of Singapore
mbiyum@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
The (BP)GAP Between Signaling Pathways
To grow or not to grow?
Gender Gaps in Science: BIOS 2017 Panel Discussion on Women in Science
MBI hosted BIOS2017 on Friday, the 15th of September. The scientific talks were followed by an hour-long panel discussion that was aimed at bringing out the various contributing factors towards gender gaps at work place.
BIOS 2017: Post-event report
MBI NUS hosted BIOS2017 on 15th of September. BIOS, a MBI Women in Science initiative, is a unique national-level biology symposium that aims to bring together women researchers in Singapore from diverse realms of life sciences research.
Yu Miao
Research Fellow
Recent Publications
- Huang M, Chen Y, Liang C, Narayan OP, Stallings C, Yu M, Traugot C, Li L, Li K, Vo Q, Wang H, Chou Y, Cech L, Parra D, Garzon L, Parsons D, Diaz E, Zhang C, Mackey C, Sussman H, Zmirska I, Chung M, Zhou C, Glynatsis G, Siemann DW, Licht JD, Li C, Kaye FJ, Xie M, Tan Y, Wu L, Bivona TG, Guan J, and Tang X. Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability. Biomaterials 2025; 329:123920. [PMID: 41443038]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Le S, Yu M, Fu C, Heier JA, Martin S, Hardin J, and Yan J. Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction. Proc Natl Acad Sci U S A 2024; 121(37):e2400654121. [PMID: 39236238]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Yu M, Lu J, Le S, and Yan J. Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature. J Phys Chem Lett 2021;:7914-7920. [PMID: 34384021]
- Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD, Jørgensen C, Humphries MJ, and Goult BT. Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. J Biol Chem 2021;:100837. [PMID: 34118235]
- Yu M, Zhao Z, Chen Z, Le S, and Yan J. Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains. Nat Commun 2020; 11(1):4476. [PMID: 32900995]
- Le S, Yu M, and Yan J. Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin-talin/α-catenin linkages. Sci Adv 2019; 5(12):eaav2720. [PMID: 31897422]
- Le S, Yu M, Bershadsky A, and Yan J. Mechanical regulation of formin-dependent actin polymerization. Semin. Cell Dev. Biol. 2019;. [PMID: 31813767]
- Le S, Yu M, and Yan J. Phosphorylation Reduces the Mechanical Stability of the α-Catenin/ β-Catenin Complex. Angew. Chem. Int. Ed. Engl. 2019;. [PMID: 31625226]
