WANG Yejun
Alumni, Mechanobiology Institute, National University of Singapore
mbiwye@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
Zihao Wu
Alumni, Chan Group
MBI PIs win MOE AcRF Tier 3 grant to study endomembrane aging
A research team led by Mechanobiology Institute (MBI) Principal Investigators Assoc. Prof. Tony Kanchanawong and Prof. Rong Li was recently awarded a Ministry of Education Academic Research Fund (MOE AcRF) Tier 3 grant.
Preventing mistakes in chromosomal segregation
A recent study from the Li Lab at the Mechanobiology Institute, National University of Singapore and Johns Hopkins University, USA has revealed new aspects on the involvement of p53 protein in preventing mistakes in chromosomal segregation. Learn more
Jin Zhu
Senior Research Fellow, Facility Manager
Wan Jun Gan
Research Fellow, Chan Group
Meng Yue
Research Assistant, Class of January 2021, Kanchanawong Group
Wang Yejun
Alumni
I decided to switch into the world of biology after I received my BS in chemistry from Zhejiang University. With the interest in things happening inside nucleus, I joined Prof. Shiva’s lab as a graduate student, to study the role of external mechanical signals on gene regulation in eukaryotic cells. During my first one and a half years I developed a method to visualize active transcription sites on open chromatin spreads using super-resolution microscopy. Presently I’m studying the role of cell geometric constraints on 3D organization of chromosomes by using multiple techniques such as fluorescence in situ hybridization (FISH), confocal imaging, and super-resolution imaging.
Recent Publications
- Wang Y, Li X, Xia R, Wan Y, Lu J, Zhao Z, Zhang W, Wang Q, Saunders TE, and Yin J. Hedgehog-driven adaxial cell constriction patterns slow muscle fate and somite boundary remodeling in the presomitic mesoderm. Cell Rep 2026; 45(5):117319. [PMID: 42065961]
- Yang J, Guan Z, Zeng D, Qin Y, Zhao C, Wang S, Wu Q, Wang Q, Li H, Wu J, Huang H, Wang Y, Wu E, Thalmann NM, Lim CT, Wong TY, Jia W, Li H, Fregni F, and Sheng B. Extended reality in clinical neurology: From interdisciplinary innovations to clinical practice. Cell Rep Med 2026;:102696. [PMID: 41903546]
- Yang B, Li B, Zhu Y, Zhao M, Cheng Y, Zhao X, En-Jie DT, Wang Y, Zhang M, Tang X, Jin S, Sun Y, Zhang X, Xue B, Yan J, Wu G, Lin Z, Luo M, Yu H, Zhang L, Chen X, and Ni Q. Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. Nat Nanotechnol 2026;. [PMID: 41772191]
- Liu X, Liu J, Wang Y, Yao M, Baker KB, Klapholz B, Brown NH, Goult BT, and Yan J. The mechanical response of vinculin. Sci Adv 2025; 11(44):eady6949. [PMID: 41171905]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Wang W, Huang Z, Wang Y, Li H, and Kanchanawong P. Vortex Interference Enables Optimal 3D Interferometric Nanoscopy. Phys Rev Lett 2025; 134(7):073802. [PMID: 40053988]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Morales-Camilo N, Liu J, Ramírez MJ, Canales-Salgado P, Alegría JJ, Liu X, Ong HT, Barrera NP, Fierro A, Toyama Y, Goult BT, Wang Y, Meng Y, Nishimura R, Fong-Ngern K, Low CSL, Kanchanawong P, Yan J, Ravasio A, and Bertocchi C. Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction. Nat Commun 2024; 15(1):5608. [PMID: 38969637]
- Zhang X, Ruan L, Wang H, Zhu J, Li T, Sun G, Dong Y, Wang Y, Berreby G, Shay A, Chen R, Ramachandran S, Dawson VL, Dawson TM, and Li R. Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity. NPJ Parkinsons Dis 2024; 10(1):120. [PMID: 38906862]
