SAW Thuan Beng
Alumni, Research Associate, Mechanobiology Institute, National University of Singapore
mbistb@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What are chromatin, heterochromatin and euchromatin?
What is chromatin, heterochromatin and euchromatin? The human genome contains over 3 billion base pairs or nucleotides. These nucleotides, which are arranged in a linear sequence along DNA (deoxyribonucleic acid), encode every protein and [...]
What are chromosomes and chromosome territories?
What are chromosomes and chromosome territories? While metaphase chromosomes can be depicted as distinct bodies with well-defined shapes and sizes, interphase chromosomes are less uniform and, by filling the nuclear space, difficult to distinguish. [...]
How is DNA replicated?
How is DNA replicated? Cells must replicate their DNA before they can divide. This ensures that each daughter cell gets a copy of the genome, and therefore, successful inheritance of genetic traits. DNA replication [...]
How is transcription regulated in stem cells?
How is transcription regulated in stem cells? Pluripotent stem cells can potentially differentiate into any given cell type. They commonly exhibit mechanically softer nuclei [1], lack type-A lamins [2] and have a poorly defined [...]
How does chromatin remodeling impact gene transcription?
How does chromatin remodeling impact gene transcription? While chromosome territory dynamics is believed to regulate gene expression through the redistribution of genes and the subsequent co-localization of these genes with transcription machinery, changes are [...]
What are transcription factories?
What are transcription factories? The primary role of chromatin assembly is the compaction of an otherwise very long DNA molecule into discrete structures that fit into the nucleus. However, this compaction cannot be achieved [...]
Saw Thuan Beng
Alumni, Research Associate
Principal Investigator
Research Interests
Recent Publications
- Jiang X, Xu P, Feng F, Grenci G, and Saw TB. Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device. J Vis Exp 2025;(223). [PMID: 41052031]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Delanoë-Ayari H, Hiraiwa T, Marcq P, Rieu J, and Saw TB. 2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications. Int J Biochem Cell Biol 2023;:106432. [PMID: 37290687]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33603188]
- Teo JL, Lim CT, Yap AS, and Saw TB. A Biologist's Guide to Traction Force Microscopy Using Polydimethylsiloxane Substrate for Two-Dimensional Cell Cultures. STAR Protoc 2020; 1(2):100098. [PMID: 33111126]
- Chen T, Saw TB, Mège R, and Ladoux B. Mechanical forces in cell monolayers. J. Cell. Sci. 2018; 131(24). [PMID: 30573527]
- Saw TB, Xi W, Ladoux B, and Lim CT. Biological Tissues as Active Nematic Liquid Crystals. Adv. Mater. Weinheim 2018;:e1802579. [PMID: 30156334]
- Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
