SAW Thuan Beng
Alumni, Research Associate, Mechanobiology Institute, National University of Singapore
mbistb@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What is caveolar endocytosis?
What is caveolar endocytosis? Macropinocytosis or ‘cell drinking’ is a type of endocytosis that involves the nonspecific uptake of extracellular material, such as soluble molecules, nutrients, and antigens. First observed in 1931 by Warren [...]
What is the nucleus?
What is the nucleus? The nucleus is an organelle found in most eukaryotic cells, the exception being red blood cells. In animal cells it is both the largest and stiffest organelle and is easily [...]
How does the nucleus facilitate mechanotransduction?
What properties of the nucleus facilitate mechanotransduction? Similar to the concept of long distance force propagation along the cytoskeleton, the prestressed nuclear state, which counterbalances intracellular forces from the cytoskeleton, enables mechanotransduction [1][2]. Both [...]
How is nuclear “prestress” maintained?
How is nuclear “prestress” maintained? As an integral part of cellular behavior, cells are sensitive to matrix rigidity, local geometry and stress or strain applied by external factors [1]. In recent years, it has [...]
How is the nucleus coupled to the cytoskeleton?
How is the nucleus coupled to the cytoskeleton? Cytoskeletal filaments bridge the nucleus to the plasma membrane, which in turn is anchored at sub-cellular sites to extracellular substrates via a plethora of proteins that [...]
What are chromatin, heterochromatin and euchromatin?
What is chromatin, heterochromatin and euchromatin? The human genome contains over 3 billion base pairs or nucleotides. These nucleotides, which are arranged in a linear sequence along DNA (deoxyribonucleic acid), encode every protein and [...]
Saw Thuan Beng
Alumni, Research Associate
Principal Investigator
Research Interests
Recent Publications
- Jiang X, Xu P, Feng F, Grenci G, and Saw TB. Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device. J Vis Exp 2025;(223). [PMID: 41052031]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Delanoë-Ayari H, Hiraiwa T, Marcq P, Rieu J, and Saw TB. 2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications. Int J Biochem Cell Biol 2023;:106432. [PMID: 37290687]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33603188]
- Teo JL, Lim CT, Yap AS, and Saw TB. A Biologist's Guide to Traction Force Microscopy Using Polydimethylsiloxane Substrate for Two-Dimensional Cell Cultures. STAR Protoc 2020; 1(2):100098. [PMID: 33111126]
- Chen T, Saw TB, Mège R, and Ladoux B. Mechanical forces in cell monolayers. J. Cell. Sci. 2018; 131(24). [PMID: 30573527]
- Saw TB, Xi W, Ladoux B, and Lim CT. Biological Tissues as Active Nematic Liquid Crystals. Adv. Mater. Weinheim 2018;:e1802579. [PMID: 30156334]
- Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
