SAW Thuan Beng
Alumni, Research Associate, Mechanobiology Institute, National University of Singapore
mbistb@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What is actin nucleation?
What is actin nucleation? The first step in actin polymerization is known as ‘nucleation’. This step sees the formation of an actin nucleus, which is essentially a complex of three actin monomers, from which [...]
How does Arp2/3-mediate the nucleation of branched filaments?
How does Arp2/3-mediate the nucleation of branched filaments? The Arp2/3 complex is composed of 7 evolutionarily conserved subunits (Arp2, Arp3, ARPC1-C5) that are structurally similar to the barbed end of actin [1]. The complex [...]
How are actin filaments distributed in cells and tissues?
How are actin filaments distributed in cells and tissues? Actin filaments are widely distributed throughout cells, forming a range of cytoskeletal structures and contributing to an even broader range of processes. Some of the [...]
How do actin filaments grow?
How do actin filaments grow? Actin Filaments (F-actin) grow from the polymerization of G-actin monomers Actin is a highly abundant (10-100 micromolar on average),~42 kDa structural protein found in all eukaryotic cells (except for [...]
What are the functions of actin filaments?
What are the functions of actin filaments? Several biological processes related to cell shape and movement depend on actin filaments (reviewed in [1]). Some keys functions are: To form the dynamic cytoskeleton, which gives [...]
What factors influence actin filament length and treadmilling?
What factors influence actin filament length and treadmilling? Several factors influence actin filament length and treadmilling. ATP binding on G-actin and free ATP-G-actin concentration ATP-binding on actin subunits modulates the dynamics of filament assembly, [...]
Saw Thuan Beng
Alumni, Research Associate
Principal Investigator
Research Interests
Recent Publications
- Jiang X, Xu P, Feng F, Grenci G, and Saw TB. Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device. J Vis Exp 2025;(223). [PMID: 41052031]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Delanoë-Ayari H, Hiraiwa T, Marcq P, Rieu J, and Saw TB. 2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications. Int J Biochem Cell Biol 2023;:106432. [PMID: 37290687]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33603188]
- Teo JL, Lim CT, Yap AS, and Saw TB. A Biologist's Guide to Traction Force Microscopy Using Polydimethylsiloxane Substrate for Two-Dimensional Cell Cultures. STAR Protoc 2020; 1(2):100098. [PMID: 33111126]
- Chen T, Saw TB, Mège R, and Ladoux B. Mechanical forces in cell monolayers. J. Cell. Sci. 2018; 131(24). [PMID: 30573527]
- Saw TB, Xi W, Ladoux B, and Lim CT. Biological Tissues as Active Nematic Liquid Crystals. Adv. Mater. Weinheim 2018;:e1802579. [PMID: 30156334]
- Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
