Porin Gene Transcription in Single Cells
Transcription of GFP enables us to see how expression levels change in response to osmolality
The Mechanism of Osmosensing by EnvZ and other HKs
Mapping conformational changes in EnvZ associated with osmotic stress
Molecular Mechanisms of Mechanotransduction
Molecular machines sense and transduce mechanical force
Kriti Sethi
Research Fellow, Li Group
Persistent a-Catenin Activation
Switching behavior of a-Catenin at E-cadherin adhesions
Cell Extrusion Mechanisms
Making sure to expel an unwanted cell
Ding Wei Yung
Alumni
Principal Investigator
Research Interests
Cell-Matrix and Cell-Cell Mechanotransduction, Molecular Mechanisms of Mechanobiology
Wei Yung’s interest lies in understanding the sophistication of cells as robust machines. Using C. elegans, a 1mm nematode, as a model system, he investigates the cellular machinery underlying newly fertilized zygotes that drives critical force-dependent processes such as polarization and cytokinesis.
Biography
Wei Yung completed his Bachelor’s degree in Bioengineering (Second Class Upper) from the National University of Singapore in 2012. In his honors dissertation under the co-supervision of Professor James Goh and Professor Wong Hee Kit, he optimized the conditions required for the construction of interbody spinal fusion device using primary adipose stem cells seeded in a biodegradable polycaprolactone/tricalcium sulphate (PCL/TCP) scaffold. The work was presented in the Bioengineering Showcase 2012 and he was awarded the Best Poster Award. After he was enrolled in the Mechanobiology Graduate Program, he joined Dr. Zaidel-Bar’s Cell Adhesion and Morphogenesis Lab and is currently searching for novel genes involved in regulating C. elegans early embryogenesis.
