Bibhas ROY
Visiting Research Fellow, Mechanobiology Institute, National University of Singapore, Post-doctoral Fellow, FIRC Institute of Molecular Oncology (IFOM), Italy
mbibr@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
2017 UNESCO Symposium: Cracking the Code: Girls Education in STEM, a report
The symposium explored multi-pronged approaches to tackle gender gaps in STEM education at the individual, family & peers, schools/educational institutions, society and government levels.
Sree Vaishnavi Sundararajan
Alumni, Grenci Group
Mona Suryana
Research Associate, Grenci Group
Jegan Vishnuwardhana Shanmugarajah
Research Assistant, Grenci Group
Breaking cell symmetry
A force driven mechanism for establishing cell polarity
MBI welcomes students from Huazhong University of Science and Technology, China
On August 16th, a group of 13 students from the Huazhong University of Science and Technology (HUST), China visited the Mechanobiology Institute (MBI), National University of Singapore to learn more about scientific research in Singapore.
Bibhas Roy
Alumni
I am a Research Fellow in Nuclear Mechanics & Genome Regulation Laboratory at MBI. In my doctoral research at Indian Institute of Technology Kharagpur, I have been understanding about the cellular mechanotransduction which specifically deals with cell membrane mechanosensors and consequent downstream cell responses. Eventually I have quite interested on nuclear mechanotransduction because for last two decades several path breaking findings in cellular mechanobiology has gained enormous interest to scientific community, but the nuclear mechanotransduction field remains quite elusive. This drive brought me to Prof Shivashankar’s Lab at MBI.
During differentiation and also reprogramming, cells accumulated multiple epigenetic changes, which leads to differential type of gene expression in different cell types. My current endeavor explores how nuclear geometry driven epigenetic changes leads to different cell type commitment.
Recent Publications
- Yuan L, Roy B, Ratna P, Uhler C, and Shivashankar GV. Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions. Sci Rep 2022; 12(1):17318. [PMID: 36243826]
- Roy B, Yuan L, Lee Y, Bharti A, Mitra A, and Shivashankar GV. Fibroblast rejuvenation by mechanical reprogramming and redifferentiation. Proc. Natl. Acad. Sci. U.S.A. 2020;. [PMID: 32350144]
- Banerjee H, Roy B, Chaudhury K, Srinivasan B, Chakraborty S, and Ren H. Frequency-induced morphology alterations in microconfined biological cells. Med Biol Eng Comput 2018;. [PMID: 30415434]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
