Saradha VENKATACHALAPATHY
PhD Student, Mechanobiology Institute, National University of Singapore
E0018317@u.nus.edu
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What are cell-matrix receptors?
What are cell-matrix receptors? Interaction between cell-matrix receptors and their respective ligands are often the initial step in the formation of a cell-matrix adhesion. Several types of cell-matrix receptors have been identified, each interacting [...]
What is parvin?
What is parvin? The parvins are a family of actin binding proteins (known as α-, β- and γ-parvin in mammals) that are members of the actin linking functional module at cell-matrix adhesion sites (reviewed [...]
What is talin?
What is talin? Talin contains a 47-kDa N-terminal head, a neck and a 220kDa rod domain. The head domain comprises four subdomains termed F0, F1, F2 and F3, with the latter three forming a [...]
What is tensin?
What is tensin? Tensin is a cytoskeleton scaffolding protein that was named for its ability to form a bridge that maintains tension between the actin filaments and cell-matrix adhesion sites (reviewed in [1]). A [...]
What is vinculin?
What is Vinculin? Vinculin is a protein that couples, transmits, transduces, and regulates mechanical force between the cytoskeleton and adhesion receptors (reviewed in [1]). Vinculin frequently links adhesion receptors (e.g. integrins) to the contractile [...]
What is zyxin?
What is Zyxin? Zyxin is enriched along actin filaments, stress fiber bundles, and at cell-cell or cell-matrix adhesion sites [1][2]. Zyxin is specifically found in more mature adhesions [3] and its absence in early [...]
Saradha Venkatachalapathy
PhD Student
Recent Publications
- Venkatachalapathy S, Sreekumar D, Ratna P, and Shivashankar GV. Actomyosin contractility as a mechanical checkpoint for cell state transitions. Sci Rep 2022; 12(1):16063. [PMID: 36163393]
- Venkatachalapathy S, Jokhun DS, Andhari M, and Shivashankar GV. Single cell imaging-based chromatin biomarkers for tumor progression. Sci Rep 2021; 11(1):23041. [PMID: 34845273]
- Yang KD, Belyaeva A, Venkatachalapathy S, Damodaran K, Katcoff A, Radhakrishnan A, Shivashankar GV, and Uhler C. Multi-domain translation between single-cell imaging and sequencing data using autoencoders. Nat Commun 2021; 12(1):31. [PMID: 33397893]
- Yang KD, Damodaran K, Venkatachalapathy S, Soylemezoglu AC, Shivashankar GV, and Uhler C. Predicting cell lineages using autoencoders and optimal transport. PLoS Comput. Biol. 2020; 16(4):e1007828. [PMID: 32343706]
- Venkatachalapathy S, Jokhun DS, and Shivashankar GV. Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments. Mol. Biol. Cell 2020;:mbcE19080420. [PMID: 32023167]
- Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan AV, Sharma Jokhun D, Shenoy VB, and Shivashankar GV. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol. Biol. Cell 2018;:mbcE18040256. [PMID: 30256731]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
- Belyaeva A, Venkatachalapathy S, Nagarajan M, Shivashankar GV, and Uhler C. Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 29229825]
- Radhakrishnan AV, Jokhun DS, Venkatachalapathy S, and Shivashankar GV. Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry. Biophys. J. 2017; 112(9):1920-1928. [PMID: 28494962]
- Mitra A, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, and Shivashankar GV. Cell geometry dictates TNFα-induced genome response. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 28461498]
