Saradha VENKATACHALAPATHY
PhD Student, Mechanobiology Institute, National University of Singapore
E0018317@u.nus.edu
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What are actin comet tails?
What are actin comet tails? Actin comet tails are actin structures formed by the dynamic polymerization of actin beneath some species of intracellular bacteria belonging to the genus Listeria, Shigella, Ricketssia, Mycobacterium and Burkholderia. [...]
What is cell migration?
What is cell migration? Cell migration is the directed movement of a single cell or a group of cells in response to chemical and/or mechanical signals. It is a fundamental cellular process that occurs [...]
What are epithelial tubes?
What are epithelial tubes? Tubulogenesis, or the formation of tubes, is one of the fundamental morphogenetic events taking place during development. Several major organs, such as the respiratory, circulatory, and secretory systems, are constituted [...]
How is dorsal closure controlled by mechanics?
How is dorsal closure controlled by mechanics? A number of studies, which describe the cellular mechanisms and signaling pathways underlying dorsal closure, have pointed towards a mechanical basis for the morphogenetic changes associated with [...]
How does the vascular system form?
How does the vascular system form? What is vasculogenesis? Vasculogenesis refers to the morphogenetic process occurring during the earliest stages of embryonic development by which a de novo vascular system, consisting of the heart [...]
How do cardiomyocytes differentiate?
How do cardiomyocytes differentiate? Cardiomyocytes are the chief cell type in the heart and their coordinated contraction as a mass is responsible for the pumping of blood around the developing embryo. Cardiac specification occurs [...]
Saradha Venkatachalapathy
PhD Student
Recent Publications
- Venkatachalapathy S, Sreekumar D, Ratna P, and Shivashankar GV. Actomyosin contractility as a mechanical checkpoint for cell state transitions. Sci Rep 2022; 12(1):16063. [PMID: 36163393]
- Venkatachalapathy S, Jokhun DS, Andhari M, and Shivashankar GV. Single cell imaging-based chromatin biomarkers for tumor progression. Sci Rep 2021; 11(1):23041. [PMID: 34845273]
- Yang KD, Belyaeva A, Venkatachalapathy S, Damodaran K, Katcoff A, Radhakrishnan A, Shivashankar GV, and Uhler C. Multi-domain translation between single-cell imaging and sequencing data using autoencoders. Nat Commun 2021; 12(1):31. [PMID: 33397893]
- Yang KD, Damodaran K, Venkatachalapathy S, Soylemezoglu AC, Shivashankar GV, and Uhler C. Predicting cell lineages using autoencoders and optimal transport. PLoS Comput. Biol. 2020; 16(4):e1007828. [PMID: 32343706]
- Venkatachalapathy S, Jokhun DS, and Shivashankar GV. Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments. Mol. Biol. Cell 2020;:mbcE19080420. [PMID: 32023167]
- Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan AV, Sharma Jokhun D, Shenoy VB, and Shivashankar GV. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol. Biol. Cell 2018;:mbcE18040256. [PMID: 30256731]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
- Belyaeva A, Venkatachalapathy S, Nagarajan M, Shivashankar GV, and Uhler C. Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 29229825]
- Radhakrishnan AV, Jokhun DS, Venkatachalapathy S, and Shivashankar GV. Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry. Biophys. J. 2017; 112(9):1920-1928. [PMID: 28494962]
- Mitra A, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, and Shivashankar GV. Cell geometry dictates TNFα-induced genome response. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 28461498]
