Saradha VENKATACHALAPATHY
PhD Student, Mechanobiology Institute, National University of Singapore
E0018317@u.nus.edu
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What is Arf6-associated endocytosis?
What is Arf6-associated endocytosis? Arf6-associated endocytosis is a clathrin-independent, plasma membrane-endosomal recycling pathway, regulated by the Arf6 protein, which is a member of the Arf family of small GTPases [1]. In this pathway, Arf6 [...]
What is Rho-dependent IL-2 receptor endocytosis?
What is Rho-dependent IL-2 receptor endocytosis? Internalization of transmembrane receptors was thought to occur exclusively via clathrin-mediated endocytosis (CME). However, the discovery of clathrin-independent endocytic routes, in particular, the pathway that mediates the internalization [...]
What is flotillin-associated endocytosis?
What is flotillin-associated endocytosis? Flotillins, which are proteins that localize to specific microdomains or lipid rafts in the plasma membrane, mediate a clathrin-independent endocytosis pathway that is regulated by the Src family tyrosine kinase [...]
What is Fast Endophilin-Mediated Endocytosis (FEME)?
What is Fast Endophilin-Mediated Endocytosis (FEME)? FEME is a novel clathrin-independent endocytic pathway, regulated by the BAR domain protein endophilin, where tubulo-vesicular carriers form within seconds at the plasma membrane upon activation of specific [...]
What is autophagy?
What is autophagy? Autophagy, meaning self-eating, is an intracellular degradation system wherein unwanted cargo, such as old or damaged organelles, unneeded proteins, as well as pathogenic agents, are digested and the macromolecular contents from [...]
Genome Regulation
Genome Regulation Genome regulation encompasses all facets of gene expression, from the biochemical modifications of DNA, to the physical arrangement of chromosomes and the activity of the transcription machinery. The genome regulation programs that [...]
Saradha Venkatachalapathy
PhD Student
Recent Publications
- Venkatachalapathy S, Sreekumar D, Ratna P, and Shivashankar GV. Actomyosin contractility as a mechanical checkpoint for cell state transitions. Sci Rep 2022; 12(1):16063. [PMID: 36163393]
- Venkatachalapathy S, Jokhun DS, Andhari M, and Shivashankar GV. Single cell imaging-based chromatin biomarkers for tumor progression. Sci Rep 2021; 11(1):23041. [PMID: 34845273]
- Yang KD, Belyaeva A, Venkatachalapathy S, Damodaran K, Katcoff A, Radhakrishnan A, Shivashankar GV, and Uhler C. Multi-domain translation between single-cell imaging and sequencing data using autoencoders. Nat Commun 2021; 12(1):31. [PMID: 33397893]
- Yang KD, Damodaran K, Venkatachalapathy S, Soylemezoglu AC, Shivashankar GV, and Uhler C. Predicting cell lineages using autoencoders and optimal transport. PLoS Comput. Biol. 2020; 16(4):e1007828. [PMID: 32343706]
- Venkatachalapathy S, Jokhun DS, and Shivashankar GV. Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments. Mol. Biol. Cell 2020;:mbcE19080420. [PMID: 32023167]
- Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan AV, Sharma Jokhun D, Shenoy VB, and Shivashankar GV. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol. Biol. Cell 2018;:mbcE18040256. [PMID: 30256731]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
- Belyaeva A, Venkatachalapathy S, Nagarajan M, Shivashankar GV, and Uhler C. Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 29229825]
- Radhakrishnan AV, Jokhun DS, Venkatachalapathy S, and Shivashankar GV. Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry. Biophys. J. 2017; 112(9):1920-1928. [PMID: 28494962]
- Mitra A, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, and Shivashankar GV. Cell geometry dictates TNFα-induced genome response. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 28461498]
