Saradha VENKATACHALAPATHY
PhD Student, Mechanobiology Institute, National University of Singapore
E0018317@u.nus.edu
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What are filopodia?
What are filopodia? Filopodia (singular filopodium) are thin membrane protrusions that act as antennae for a cell to probe the surrounding environment [1][2][3]. Nonprotruding filopodia are mechanistically related to microspikes [4]. Filopodia are commonly [...]
What is the first step in filopodium formation?
What is the first step in filopodium formation? Actin nucleation initiates filopodium formation The first step in the formation of a filopodium is the nucleation of actin filaments from G-actin monomers. This is facilitated [...]
How does cross-linking of actin filaments aid in filopodia extension?
How does cross-linking of actin filaments aid in filopodia extension? Once nucleation has taken place, actin filaments begin to extend. This process is primarily facilitated by members of the formin family of proteins, however [...]
How do filopodia attach to the surrounding substrate?
How do filopodia attach to the surrounding substrate? A diverse array of cellular responses can result when a filopodium makes contact with a ligand or substrate. These responses are dependent on the coupling of [...]
How do filopodia move dynamically?
What causes filopodia retraction and collapse? Binding of filopodia to certain ligands or substratum may hinder filament assembly, thereby leading to changes that promote retraction, collapse or growth cone turning [1][2]. For example, substrate [...]
What are lamellipodia and lamella?
What are lamellipodia and lamella? The lamellipodia and lamella are plate-like extensions of the cell that play crucial roles in both cell motility and migration, and mechanosensing. These structures form and function over distinct [...]
Saradha Venkatachalapathy
PhD Student
Recent Publications
- Venkatachalapathy S, Sreekumar D, Ratna P, and Shivashankar GV. Actomyosin contractility as a mechanical checkpoint for cell state transitions. Sci Rep 2022; 12(1):16063. [PMID: 36163393]
- Venkatachalapathy S, Jokhun DS, Andhari M, and Shivashankar GV. Single cell imaging-based chromatin biomarkers for tumor progression. Sci Rep 2021; 11(1):23041. [PMID: 34845273]
- Yang KD, Belyaeva A, Venkatachalapathy S, Damodaran K, Katcoff A, Radhakrishnan A, Shivashankar GV, and Uhler C. Multi-domain translation between single-cell imaging and sequencing data using autoencoders. Nat Commun 2021; 12(1):31. [PMID: 33397893]
- Yang KD, Damodaran K, Venkatachalapathy S, Soylemezoglu AC, Shivashankar GV, and Uhler C. Predicting cell lineages using autoencoders and optimal transport. PLoS Comput. Biol. 2020; 16(4):e1007828. [PMID: 32343706]
- Venkatachalapathy S, Jokhun DS, and Shivashankar GV. Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments. Mol. Biol. Cell 2020;:mbcE19080420. [PMID: 32023167]
- Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan AV, Sharma Jokhun D, Shenoy VB, and Shivashankar GV. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol. Biol. Cell 2018;:mbcE18040256. [PMID: 30256731]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
- Belyaeva A, Venkatachalapathy S, Nagarajan M, Shivashankar GV, and Uhler C. Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 29229825]
- Radhakrishnan AV, Jokhun DS, Venkatachalapathy S, and Shivashankar GV. Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry. Biophys. J. 2017; 112(9):1920-1928. [PMID: 28494962]
- Mitra A, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, and Shivashankar GV. Cell geometry dictates TNFα-induced genome response. Proc. Natl. Acad. Sci. U.S.A. 2017;. [PMID: 28461498]
