Bibhas ROY
Visiting Research Fellow, Mechanobiology Institute, National University of Singapore, Post-doctoral Fellow, FIRC Institute of Molecular Oncology (IFOM), Italy
mbibr@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
Seeking Postdoctoral Research Fellow in the research group of Dr. Tsuyoshi Hirashima at the Mechanobiology Institute, NUS ( Cloned )
We are seeking to recruit a Postdoctoral Research Fellow in the Collective Cell Dynamics in Mammalian Development and Reproduction Laboratory at the Mechanobiology Institute, NUS.
MBI Researchers Identify a Signalling Pathway in Stiff Ovarian Tissue Affecting Egg Maturation
A joint study between the Li and Young Labs at MBI, together with A*STAR's Institute of Molecular and Cell Biology, pinpoints the molecular switch responsible for matrix stiffness in ageing ovaries, offering an alternative way to treat age-related infertility without having to reverse stiffness.
MBI to host EMBO Workshop on Cell and Tissue Mechanics of Aging and Regeneration
Organised and hosted by MBI, this EMBO Workshop will be held on 21-24 September 2027 at the Shaw Foundation Alumni House, NUS. Please click on the link to register your interest: https://coming-soon.embo.org/gw27-14
Seeking Research Fellow in Cardiac Organoids and Microphysiological Systems at the Mechanobiology Institute, NUS
The laboratory of Prof. Hanry Yu seeks to to recruit a Research Fellow in Cardiac Organoids and Microphysiological Systems at the Mechanobiology Institute, NUS.
Xiangfu Guo
Research Fellow, Yan Jie Group
Chu Đặng Khánh Hoà
Research Assistant, Dye & Michelot Groups
Bibhas Roy
Alumni
I am a Research Fellow in Nuclear Mechanics & Genome Regulation Laboratory at MBI. In my doctoral research at Indian Institute of Technology Kharagpur, I have been understanding about the cellular mechanotransduction which specifically deals with cell membrane mechanosensors and consequent downstream cell responses. Eventually I have quite interested on nuclear mechanotransduction because for last two decades several path breaking findings in cellular mechanobiology has gained enormous interest to scientific community, but the nuclear mechanotransduction field remains quite elusive. This drive brought me to Prof Shivashankar’s Lab at MBI.
During differentiation and also reprogramming, cells accumulated multiple epigenetic changes, which leads to differential type of gene expression in different cell types. My current endeavor explores how nuclear geometry driven epigenetic changes leads to different cell type commitment.
Recent Publications
- Yuan L, Roy B, Ratna P, Uhler C, and Shivashankar GV. Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions. Sci Rep 2022; 12(1):17318. [PMID: 36243826]
- Roy B, Yuan L, Lee Y, Bharti A, Mitra A, and Shivashankar GV. Fibroblast rejuvenation by mechanical reprogramming and redifferentiation. Proc. Natl. Acad. Sci. U.S.A. 2020;. [PMID: 32350144]
- Banerjee H, Roy B, Chaudhury K, Srinivasan B, Chakraborty S, and Ren H. Frequency-induced morphology alterations in microconfined biological cells. Med Biol Eng Comput 2018;. [PMID: 30415434]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
