Alpha-actinin α-actinin is an actin-binding protein [1] and component of the actin crosslinking functional modules; it lacks G-actin binding activity and lacks actin initiation/nucleation activity [2]. α-actinin is an important organizer of the cytoskeleton [...]

Filamin The filamin family of proteins bind to both actin and a number of signaling molecules including Rho GTPases. Evidence for this was shown with the loss of Filamin-A in M2 Melanoma cells, which [...]

How are intermediate filaments assembled? The soluble subunit for creating intermediate filaments is a tetramer. The tetramer is created from monomers in a stepwise fashion (as reviewed in [1]). First, two monomers associate via [...]

What is capping protein? Capping protein is involved in actin filament assembly and disassembly Capping proteins control access to the free barbed ends of actin filaments and is therefore a major factor affecting actin [...]

How is microtubule assembly/disassembly regulated? GTP hydrolysis has been shown to be a key regulator of microtubule polymerization dynamics. Although the exact mechanisms are poorly understood, two opposing models have been proposed to describe [...]

What is the role of microtubules in mechanotransduction? Microtubules exist in all cells, however their influence in the mechanotransduction of mechanical stimuli has been described at length in cardiac striated muscle [1]. Mechanical stimuli [...]