MBInsights: Science and Research HubManagement2016-11-16T06:54:04+08:00

How Structural Imbalance Drives Inflammatory Signaling in Senescent Cells

By Brenda Lau Yee Shu|Feb 6th, 2026|Categories: Low BC Lab, Low BC Lab News, MBInsights, Science Features|

In a study published in Molecular Biology of the Cell led by Celestine Ho at the Mechanobiology Institute, NUS, researchers discover that HIF-1α-activation in SASP is a defining feature of the SASP induced by diverse stressors, acting independently of micronuclei generation and cGAS/STING activation.

About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
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