How are clathrin-coated vesicles uncoated?

How are clathrin-coated vesicles uncoated? Uncoating is the process by which clathrin is removed from clathrin-coated vesicles (CCVs). In mammals, this ATP dependent process is driven by the 70kDa molecular chaperone ‘Heat shock cognate protein’. Although the exact mechanics of clathrin disassembly remain unclear, [...]

By Management|2024-03-15T15:36:35+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on How are clathrin-coated vesicles uncoated?

How are clathrin-coated vesicles transported?

How are clathrin-coated vesicles transported? Different cytoskeletal networks have been implicated in the transport of clathrin-coated vesicles (CCVs). In yeast, the actin cytoskeleton traffics dissociated CCVs [1], whilst in mammals the microtubule network transports is involved in the sorting of CCVs to distinct populations [...]

By Management|2024-03-15T15:37:40+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on How are clathrin-coated vesicles transported?

What is the CLIC/GEEC Endocytosis pathway?

What is the CLIC/GEEC Endocytosis pathway? The CLIC/GEEC (CG) pathway is a clathrin-independent endocytic pathway mediated by uncoated tubulovesicular primary carriers called clathrin-independent carriers (CLICs) which arise directly from the plasma membrane and later mature into tubular early endocytic compartments called Glycosylphosphotidylinositol- anchored protein [...]

By Management|2024-03-18T14:22:59+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on What is the CLIC/GEEC Endocytosis pathway?

What is Arf6-associated endocytosis?

What is Arf6-associated endocytosis? Arf6-associated endocytosis is a clathrin-independent, plasma membrane-endosomal recycling pathway, regulated by the Arf6 protein, which is a member of the Arf family of small GTPases [1]. In this pathway, Arf6 cycles between the inactive GDP-bound state and active GTP-bound state. [...]

By Management|2024-03-15T15:39:49+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on What is Arf6-associated endocytosis?

What is Rho-dependent IL-2 receptor endocytosis?

What is Rho-dependent IL-2 receptor endocytosis? Internalization of transmembrane receptors was thought to occur exclusively via clathrin-mediated endocytosis (CME). However, the discovery of clathrin-independent endocytic routes, in particular, the pathway that mediates the internalization of the cytokine receptor interleukin-2 (IL-2R), raises into question the [...]

By Management|2024-03-15T15:40:50+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on What is Rho-dependent IL-2 receptor endocytosis?

What is autophagy?

What is autophagy? Autophagy, meaning self-eating, is an intracellular degradation system wherein unwanted cargo, such as old or damaged organelles, unneeded proteins, as well as pathogenic agents, are digested and the macromolecular contents from the digestion are released back into the cytosol [1]. First [...]

By Management|2024-03-15T15:44:38+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on What is autophagy?

What is caveolar endocytosis?

What is caveolar endocytosis? Macropinocytosis or ‘cell drinking’ is a type of endocytosis that involves the nonspecific uptake of extracellular material, such as soluble molecules, nutrients, and antigens. First observed in 1931 by Warren Lewis while working on rat macrophages, macropinocytosis was described as [...]

By Management|2024-03-15T15:50:38+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on What is caveolar endocytosis?

What is phagocytosis?

What is phagocytosis? Phagocytosis is a process by which cells ingest large particles (> 0.5 micrometers) into membrane-bound vesicles called phagosomes, which are then targeted to the lysosomes for enzymatic degradation. The internalization of particles occur by an actin-based mechanism [1][2] and has been [...]

By Management|2024-03-15T15:51:12+08:00Nov 30th, 2023|Categories: MBInfo, Membrane Dynamics|Comments Off on What is phagocytosis?

Genome Regulation

Genome Regulation Genome regulation encompasses all facets of gene expression, from the biochemical modifications of DNA, to the physical arrangement of chromosomes and the activity of the transcription machinery. The genome regulation programs that cells engage control which proteins are produced, and to what [...]

By Management|2024-03-08T16:06:40+08:00Nov 30th, 2023|Categories: Genome Regulation, MBInfo|Comments Off on Genome Regulation

What are chromatin, heterochromatin and euchromatin?

What is chromatin, heterochromatin and euchromatin? The human genome contains over 3 billion base pairs or nucleotides. These nucleotides, which are arranged in a linear sequence along DNA (deoxyribonucleic acid), encode every protein and genetic trait in the human body. This information is contained [...]

By Management|2024-03-08T16:16:36+08:00Nov 30th, 2023|Categories: Genome Regulation, MBInfo|Comments Off on What are chromatin, heterochromatin and euchromatin?

What are chromosomes and chromosome territories?

What are chromosomes and chromosome territories? While metaphase chromosomes can be depicted as distinct bodies with well-defined shapes and sizes, interphase chromosomes are less uniform and, by filling the nuclear space, difficult to distinguish. Despite this, recent research has revealed how the nuclear architecture [...]

By Management|2024-03-08T16:18:37+08:00Nov 30th, 2023|Categories: Genome Regulation, MBInfo|Comments Off on What are chromosomes and chromosome territories?

What is the nucleus?

What is the nucleus? The nucleus is an organelle found in most eukaryotic cells, the exception being red blood cells. In animal cells it is both the largest and stiffest organelle and is easily identifiable by light microscopy. The average mammalian nucleus has a [...]

By Management|2024-03-08T16:07:24+08:00Nov 30th, 2023|Categories: Genome Regulation, MBInfo|Comments Off on What is the nucleus?

About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
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