Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
What is the mesenchymal to epithelial transition?
What is the mesenchymal-epithelial transition? During development, the transitioning of epithelial cells to a mesenchymal lineage is not an irreversible process. Instead, a number of developmental programs are accompanied by a reversal of EMT, [...]
How is hematopoiesis regulated by mechanics?
How is hematopoiesis regulated by mechanics? Once blood circulation is established during the earliest stages of hematopoiesis, the pulsatile nature of blood flow within the aorta generates a range of biomechanical forces, such as [...]
What is the cellular origin of hematopoietic stem cells?
What is the cellular origin of hematopoietic stem cells? Based on findings from a large number of anatomical, biochemical, and genetic studies carried out over the years, three major theories have been put forth [...]
What are cell-cell adhesions?
What are cell-cell adhesions? Cell-cell signaling refers to inter-cellular communication through the transduction of chemical, mechanical or electrical signals, facilitated by the formation of specialized cell-cell adhesion junctions. There are three main types of [...]
How are cell-cell adhesions regulated?
How are cell-cell adhesions regulated? Introduction to the regulation of cell-cell adhesion The assembly and disassembly of cell-cell junctions, such as adherens junctions (AJ), are regulated by a vast array of factors functioning in [...]
What is hematopoiesis?
What is hematopoiesis? The hematopoietic system, which comprises all the cellular components of the blood, is one of the earliest organ systems to evolve during embryo development. Hematopoietic stem cells (HSCs), which are rare [...]
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Prabhat Tiwari
Alumni, Saunders Group
Lee Yaelim
Research Fellow, Shivashankar Group, Li Group
Guttula Durgarao
Alumni, Yan Jie Group
Ajay Sanjay Tijore
Alumni, Low Group
Aditya Arora
Research Fellow, Viasnoff Group
Michele Crestani
Alumni, Shivashankar Group
Liu Xuan Olivia
Alumni, Low Group
Danai Kati
Alumni, Shivashankar Group
Chong Zheng Min Clarence
Alumni, Yan Jie Group
Nuclear Biomarkers
The future of disease diagnosis and therapy?
Professor Linda Kenney elected to the American Academy of Microbiology Fellowship
The MBI proudly congratulates Prof Linda Kenney, Principal Investigator at the Mechanobiology Institute, National University of Singapore, for being elected to the American Academy of Microbiology (AAM).
ISMB III – 3rd Symposium on Mechanobiology: Post Event Report
The 3rd International Symposium on Mechanobiology (ISMBIII), jointly organized by the Mechanobiology Institute and the International Society of Mechanobiology, was held between 11-14 December at University Town, National University of Singapore.
