Benoit LADOUX
Visiting Faculty, Mechanobiology Institute, National University of Singapore, Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Laboratory website
Cell Adhesion and Mechanics Lab
Research Program
Mechanotransduction in Tissues Group
Affiliations
Research Director, Université Paris Diderot & Centre National de la Recherche Scientifique (CNRS)
Brandon Goh Yeow Wee
Research Fellow, Seetharaman Group
Hana Maldivita Tambrin
Research Fellow, Seetharaman Group
Congratulations to Boon Heng for successfully defending his thesis!
Our heartfelt congratulations to Boon Heng!
Kevin Heinrich Kaub
Research Fellow, Michelot Group
Fang Zhou
Research Fellow, Holle Group
MBI warmly welcomes Shailaja Seetharaman!
MBI warmly welcomes Shailaja Seetharaman as a MBI PI leading the Vascular Mechano-Medicine Lab.
Benoit Ladoux
Visiting Faculty
Research Areas
Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction
Research Interests
Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.
Biography
With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.
Recent Publications
- Shiratsuchi N, Fujita Y, Simon de Beco , Daubech C, Ladoux B, Grata A, Levayer R, Magny E, O'Brien LE, Priya R, Mitchell SJ, Rosenblatt J, Rupprecht J, Stockmann L, Sedzinski J, Roquin L, Suzanne M, Toyama Y, Matekcic M, Trepat X, Vinzens S, Wickström SA, Lwin AKO, and Yap AS. Meeting report - CellExIt#1, the first international symposium on cell extrusion. J Cell Sci 2026; 139(14). [PMID: 42504880]
- Balasubramaniam L, Monfared S, Ardaševa A, Rosse C, Schoenit A, Dang T, Maric C, Hautefeuille M, Kocgozlu L, Chilupuri R, Dubey S, Marangoni E, L Doss B, Chavrier P, Mège R, Doostmohammadi A, and Ladoux B. Dynamic forces shape the survival fate of eliminated cells. Nat Phys 2025;. [PMID: 40636322]
- Kawaue T, Yow I, Pan Y, Le AP, Lou Y, Loberas M, Shagirov M, Teng X, Prost J, Hiraiwa T, Ladoux B, and Toyama Y. Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Dev Cell 2023;. [PMID: 36800994]
- Sonam S, Balasubramaniam L, Lin S, Ivan YMY, Jaumà IP, Jebane C, Karnat M, Toyama Y, Marcq P, Prost J, Mège R, Rupprecht J, and Ladoux B. Mechanical stress driven by rigidity sensing governs epithelial stability. Nat Phys 2022; 19:132-141. [PMID: 36686215]
- Rose N, Estrada Chavez B, Sonam S, Nguyen T, Grenci G, Bigot A, Muchir A, Ladoux B, Cadot B, Le Grand F, and Trichet L. Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials 2022; 293:121935. [PMID: 36584444]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
- . https://www.ncbi.nlm.nih.gov/pubmed/33850145
- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, and Trepat X. Addendum: Active superelasticity in three-dimensional epithelia of controlled shape. Nature 2021;. [PMID: 33846613]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
Lab Members
Hannah Abilaguyo YUSON
PhD Student, Class of August 2025, Holle Group
Diya NARANG
PhD Student, Class of August 2025, Michelot Group
QUAN Cheng
PhD Student, Class of August 2025, Li Group
CHEAM Mei Shan
PhD Student, Class of August 2025, Toyama Group
Thanks to Christiani Amorim at UC Louvain, for the kind invitation
Looking forward to new collaborations in the future!
Congratulations to Wee Juin Shin for being selected to present his work at the Amgen Scholars Asia Symposium!
Our Amgen scholar, Wee Juin Shin, has been selected to present his work on ‘the Influence of substrate curvature on theca cell nematic flow’, at the Amgen Scholar Asia Symposium in Kyoto!
Geetika Chouhan
Research Fellow, Dye Group
Seeking Research Assistant for project with MBI Fellow Dr. Tee Yee Han at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Research Assistant to work with MBI Fellow Dr. Tee Yee Han.
Seeking Research Fellow in the group of Prof. Alexander Bershadsky at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Research Fellow in the group of Prof. Alexander Bershadsky at the MBI, NUS.
Vaishnavi Rangaraj
Research Assistant, Holle Group
Liu Haoqiu
Research Fellow, Michelot Group
Seeking Postdoctoral Research Fellow for collaborative project between Dr. Yin Loon Lee and Prof. Alexander Bershadsky at the Mechanobiology Institute, NUS
The Mechanobiology Institute, NUS seeks to recruit a Postdoctoral Research Fellow for a collaborative project between Dr. Yin Loon Lee (A*STAR) and Prof. Alexander Bershadsky.
