Yusuke HARA
Alumni, Mechanobiology Institute, National University of Singapore
mbiyusu@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What is exocytosis?
What is exocytosis? Exocytosis is defined as the transport and fusion of secretory vesicles with the plasma membrane and the extracellular space. There are three exocytosis pathways that deliver vesicles to the plasma membrane. [...]
What is autophagy?
What is autophagy? Autophagy, meaning self-eating, is an intracellular degradation system wherein unwanted cargo, such as old or damaged organelles, unneeded proteins, as well as pathogenic agents, are digested and the macromolecular contents from [...]
What is caveolar endocytosis?
What is caveolar endocytosis? Macropinocytosis or ‘cell drinking’ is a type of endocytosis that involves the nonspecific uptake of extracellular material, such as soluble molecules, nutrients, and antigens. First observed in 1931 by Warren [...]
What is phagocytosis?
What is phagocytosis? Phagocytosis is a process by which cells ingest large particles (> 0.5 micrometers) into membrane-bound vesicles called phagosomes, which are then targeted to the lysosomes for enzymatic degradation. The internalization of [...]
Genome Regulation
Genome Regulation Genome regulation encompasses all facets of gene expression, from the biochemical modifications of DNA, to the physical arrangement of chromosomes and the activity of the transcription machinery. The genome regulation programs that [...]
How does the nucleus facilitate mechanotransduction?
What properties of the nucleus facilitate mechanotransduction? Similar to the concept of long distance force propagation along the cytoskeleton, the prestressed nuclear state, which counterbalances intracellular forces from the cytoskeleton, enables mechanotransduction [1][2]. Both [...]
Yusuke Hara
Alumni
Recent Publications
- Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Author Correction: Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2018;. [PMID: 29507405]
- Hara Y. Contraction and elongation: Mechanics underlying cell boundary deformations in epithelial tissue. Dev. Growth Differ. 2017;. [PMID: 28573735]
- Ding WY, Ong HT, Hara Y, Wongsantichon J, Toyama Y, Robinson RC, Nédélec F, and Zaidel-Bar R. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. J. Cell Biol. 2017;. [PMID: 28400443]
- Sun Z, Amourda C, Shagirov M, Hara Y, Saunders TE, and Toyama Y. Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension. Nat. Cell Biol. 2017;. [PMID: 28346438]
- Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege R, and Kanchanawong P. Nanoscale architecture of cadherin-based cell adhesions. Nat. Cell Biol. 2016;. [PMID: 27992406]
- Hara Y, Shagirov M, and Toyama Y. Cell Boundary Elongation by Non-autonomous Contractility in Cell Oscillation. Curr. Biol. 2016; 26(17):2388-96. [PMID: 27524484]
