YU Miao
Research Fellow, Mechanobiology Institute, National University of Singapore
mbiyum@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
Academic exchange at the Academia Sinica and National Cheng Kung University in Taiwan
Joe was invited to speak at the Institute of Physics (Academia Sinica) and the International Center for Wound Repair and Regeneration (NCKU). Great feedback on our ongoing work with exciting potential for future collaborations. Hope to be back soon!
Ong Huan Ting
Research Fellow, Young Group
Joe invited to speak at various conferences and universities in Apr and May
Joe was recently invited to speak at British Society for Cell Biology Annual Conference (UK), Hubrecht Institute (Netherlands), Paris Cite ́University (France), Collège de France (France), Reproductive Ageing Conference (USA) and MBI-Weizmann Institute joint symposium (Israel). It was also great catching up with old friends, mentors and collaborators!
Yu Miao
Research Fellow
Recent Publications
- Huang M, Chen Y, Liang C, Narayan OP, Stallings C, Yu M, Traugot C, Li L, Li K, Vo Q, Wang H, Chou Y, Cech L, Parra D, Garzon L, Parsons D, Diaz E, Zhang C, Mackey C, Sussman H, Zmirska I, Chung M, Zhou C, Glynatsis G, Siemann DW, Licht JD, Li C, Kaye FJ, Xie M, Tan Y, Wu L, Bivona TG, Guan J, and Tang X. Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability. Biomaterials 2025; 329:123920. [PMID: 41443038]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Le S, Yu M, Fu C, Heier JA, Martin S, Hardin J, and Yan J. Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction. Proc Natl Acad Sci U S A 2024; 121(37):e2400654121. [PMID: 39236238]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Yu M, Lu J, Le S, and Yan J. Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature. J Phys Chem Lett 2021;:7914-7920. [PMID: 34384021]
- Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD, Jørgensen C, Humphries MJ, and Goult BT. Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. J Biol Chem 2021;:100837. [PMID: 34118235]
- Yu M, Zhao Z, Chen Z, Le S, and Yan J. Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains. Nat Commun 2020; 11(1):4476. [PMID: 32900995]
- Le S, Yu M, and Yan J. Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin-talin/α-catenin linkages. Sci Adv 2019; 5(12):eaav2720. [PMID: 31897422]
- Le S, Yu M, Bershadsky A, and Yan J. Mechanical regulation of formin-dependent actin polymerization. Semin. Cell Dev. Biol. 2019;. [PMID: 31813767]
- Le S, Yu M, and Yan J. Phosphorylation Reduces the Mechanical Stability of the α-Catenin/ β-Catenin Complex. Angew. Chem. Int. Ed. Engl. 2019;. [PMID: 31625226]
