SAW Thuan Beng
Alumni, Research Associate, Mechanobiology Institute, National University of Singapore
mbistb@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What are septins?
What is the role of septins in infection? Host (human) septins play a role in bacterial pathogenesis [1] and in host defense mechanisms, mainly, autophagy [2]. Although actin is the most commonly exploited cytoskeletal [...]
How do bacteria modulate the host cytoskeleton?
How do bacteria modulate the host cytoskeleton? Some bacterial pathogens gain entry and subvert immune detection by surviving intracellularly. Others remain extracellular, but manipulate host pathways from outside. A common strategy employed by both [...]
What are actin comet tails?
What are actin comet tails? Actin comet tails are actin structures formed by the dynamic polymerization of actin beneath some species of intracellular bacteria belonging to the genus Listeria, Shigella, Ricketssia, Mycobacterium and Burkholderia. [...]
Mechanobiology of bacterial pathogenesis
Bacterial Pathogenesis Pathogenesis is defined as the origination and development of a disease. Insights into disease etiology and progression, the two major aspects of pathogenesis, are paramount in the prevention, management and treatment of [...]
How does the heart form?
How does the heart form? The heart is derived from the splanchnic lateral mesoderm and initially forms as two crescent-shaped endocardial plates inside the evolving pericardial cavity. As the embryo undergoes lateral and cranial [...]
What are actin pedestals?
What are actin pedestals? Actin pedestals are raised actin structures formed by the dynamic polymerization of host actin, induced by effector proteins secreted by extracellular pathogens like Enteropathogenic Escherichia coli (EPEC) and Enterohaemorrhagic Escherichia [...]
Saw Thuan Beng
Alumni, Research Associate
Principal Investigator
Research Interests
Recent Publications
- Jiang X, Xu P, Feng F, Grenci G, and Saw TB. Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device. J Vis Exp 2025;(223). [PMID: 41052031]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Delanoë-Ayari H, Hiraiwa T, Marcq P, Rieu J, and Saw TB. 2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications. Int J Biochem Cell Biol 2023;:106432. [PMID: 37290687]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33603188]
- Teo JL, Lim CT, Yap AS, and Saw TB. A Biologist's Guide to Traction Force Microscopy Using Polydimethylsiloxane Substrate for Two-Dimensional Cell Cultures. STAR Protoc 2020; 1(2):100098. [PMID: 33111126]
- Chen T, Saw TB, Mège R, and Ladoux B. Mechanical forces in cell monolayers. J. Cell. Sci. 2018; 131(24). [PMID: 30573527]
- Saw TB, Xi W, Ladoux B, and Lim CT. Biological Tissues as Active Nematic Liquid Crystals. Adv. Mater. Weinheim 2018;:e1802579. [PMID: 30156334]
- Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
