SAW Thuan Beng
Alumni, Research Associate, Mechanobiology Institute, National University of Singapore
mbistb@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
What are podosomes?
What are podosomes? Podosomes are actin-rich, adhesive structures that are present at the ventral surface of cells of the monocytic myeloid lineage, stimulated endothelial cells [1] and cultured Src-transformed cancer cells. These structures are [...]
What is the first step in podosome assembly?
What is the first step in podosome assembly? Podosome initiation and assembly is highly regulated, both spatially and temporally. Dendritic cells best exemplify the temporal regulation of podosome formation. Following activation by an antigen [...]
What mechanisms drive cytoskeleton extension within podosomes?
What mechanisms drive cytoskeleton extension within podosomes? Interactions between the extracellular matrix (ECM) and cell surface integrins leads to podosome formation. The initiating signal is transduced through mechanosensing integrins to the cytoskeleton, upon which [...]
What are stress fibers?
What are stress fibers? Stress fibers are higher order cytoskeletal structures composed of cross-linked actin filament bundles, and in many cases, myosin motor proteins, that span a length of 1-2 micrometers [1]. At least [...]
What are the functions of podosomes?
What are the functions of podosomes? Both focal adhesions and podosomes are intimately involved in cell motility, with podosomes specifically implicated in cell invasion. Invasiveness is achieved through the secretion of matrix metalloproteinases (MMPs) [...]
How is stress fiber assembly regulated?
How is stress fiber assembly regulated? Tension-dependent actin polymerization and assembly of stress fibers is influenced by many factors (reviewed in [1][2]), including differences in substrate composition [3], rigidity [4][5][6] (reviewed in [7]), cell [...]
Saw Thuan Beng
Alumni, Research Associate
Principal Investigator
Research Interests
Recent Publications
- Jiang X, Xu P, Feng F, Grenci G, and Saw TB. Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device. J Vis Exp 2025;(223). [PMID: 41052031]
- Wang Y, Wang Y, Zhu Y, Yu P, Zhou F, Zhang A, Gu Y, Jin R, Li J, Zheng F, Yu A, Ye D, Xu Y, Liu Y, Saw TB, Hu G, Lim CT, and Yu F. Angiomotin cleavage promotes leader formation and collective cell migration. Dev Cell 2024;. [PMID: 39389053]
- Delanoë-Ayari H, Hiraiwa T, Marcq P, Rieu J, and Saw TB. 2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications. Int J Biochem Cell Biol 2023;:106432. [PMID: 37290687]
- . https://www.ncbi.nlm.nih.gov/pubmed/36103541
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33750921]
- Balasubramaniam L, Doostmohammadi A, Saw TB, Narayana GHNS, Mueller R, Dang T, Thomas M, Gupta S, Sonam S, Yap AS, Toyama Y, Mège R, Yeomans JM, and Ladoux B. Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nat Mater 2021;. [PMID: 33603188]
- Teo JL, Lim CT, Yap AS, and Saw TB. A Biologist's Guide to Traction Force Microscopy Using Polydimethylsiloxane Substrate for Two-Dimensional Cell Cultures. STAR Protoc 2020; 1(2):100098. [PMID: 33111126]
- Chen T, Saw TB, Mège R, and Ladoux B. Mechanical forces in cell monolayers. J. Cell. Sci. 2018; 131(24). [PMID: 30573527]
- Saw TB, Xi W, Ladoux B, and Lim CT. Biological Tissues as Active Nematic Liquid Crystals. Adv. Mater. Weinheim 2018;:e1802579. [PMID: 30156334]
- Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
