International Conference on Genomes and AI: Post-event report
This 3-day event created a common platform for scientists, industry experts, and students to share ideas and innovations, and to facilitate fruitful discussions on how AI-based tools could be used to spur research in biological sciences.
Hilary Lappin-Scott visiting from Cardiff
Prof. Hilary Lappin-Scottvisiting MBI on 27th November, 2019, for an afternoon of talks, discussion and networking opportunities.
Actin Cytoskeleton-Based Mechanisms of Establishing Left-Right Asymmetry in Biological Systems
This mini symposium will explore exciting new findings in the study of actin cytoskeleton and its responsibility in establishing left-right asymmetry. Admission is free for all interested.
Wu Hongyi
Research Fellow, Li Group
Le Shimin
Principal Investigator
Research Interests
Molecular Mechanisms of Mechanobiology
My current research has been focused on the molecular mechanics of cell mechanotransduction studied at a single-molecule level, which forms the foundation to understand the cell migration, tissue formation and maintenance, and the mechanobiology-associated translational biomedical applications.
- Single-molecule mechanobiology and biophysics at cell-ECM adhesion and cell-cell junctions;
- Single-molecule mechanobiology and biophysics at nuclear-cytoskeletal linkages and cell cytoskeleton;
- Biophysical studies of gene regulations, DNA replication and repairs by various single-DNA manipulation assays.
Recent Publications
- Ball NJ, Turkki P, Guo Y, Tanvir MH, Le S, Chin JFL, Baker KB, Luo J, Atherton P, Brown NH, Hytönen VP, Yan J, and Goult BT. An aggregation-prone region in talin controls talin self-interactions and regulates integrin adhesion complex dynamics. Proc Natl Acad Sci U S A 2026; 123(45):e2602326123. [PMID: 42981030]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Le S, Yu M, Fu C, Heier JA, Martin S, Hardin J, and Yan J. Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction. Proc Natl Acad Sci U S A 2024; 121(37):e2400654121. [PMID: 39236238]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Sun Y, Liu X, Huang W, Le S, and Yan J. Structural domain in the Titin N2B-us region binds to FHL2 in a force-activation dependent manner. Nat Commun 2024; 15(1):4496. [PMID: 38802383]
- Huang W, Liu J, Le S, Yao M, Shi Y, and Yan J. In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein. APL Bioeng 2024; 8(1):016114. [PMID: 38435467]
- Zhou Y, Zhao X, Jiang Y, Lin DJ, Lu C, Wang Y, Le S, Li R, and Yan J. A Mechanical Assay for the Quantification of Anti-RBD IgG Levels in Finger-Prick Whole Blood. ACS Sens 2023;. [PMID: 37582229]
- Liu J, Le S, Yao M, Huang W, Tio Z, Zhou Y, and Yan J. Tension Gauge Tethers as Tension Threshold and Duration Sensors. ACS Sens 2023;. [PMID: 36731861]
- Huang W, Le S, Sun Y, Lin DJ, Yao M, Shi Y, and Yan J. Mechanical Stabilization of a Bacterial Adhesion Complex. J Am Chem Soc 2022;. [PMID: 36070862]
- Wang Y, Yao M, Baker KB, Gough RE, Le S, Goult BT, and Yan J. Force-Dependent Interactions between Talin and Full-Length Vinculin. J Am Chem Soc 2021;. [PMID: 34463480]
Full Publication List
