How do neurotrophins, collapsin, and ephrins, serve as guidance cues?
How do neurotrophins, collapsin, and ephrins, serve as guidance cues? Neurotrophins Stimulating filopodia formation A secreted guidance cue which stimulates filopodia formation in growth cones. Two examples of secreted neurotrophins, brain-derived neurotrophic factor (BDNF) [...]
What is the NF-κB pathway?
What is the NF-κB pathway? NF-κB (nuclear factor kappa light chain enhancer of activated B cells) is a family of highly conserved transcription factors that regulate many important cellular behaviours, in particular, inflammatory responses, [...]
What is the Canonical Wnt Receptor Signaling Pathway?
What is the Canonical Wnt Receptor Signaling Pathway? The canonical Wnt receptor signaling pathway is a series of molecular events that are initiated by the binding of Wnt proteins to the frizzled family of [...]
How is SRF signaling activated?
How is SRF signaling activated? Myocardin, MAL (or MRTF-A) and MRTF-B are the best-studied examples of MRTFs. In the cytoplasm, MRTFs exist in a stable complex with monomeric G-actin via RPEL domains, which exist [...]
What is the Hippo-YAP/TAZ tumor-suppressor pathway?
What is the Hippo-YAP/TAZ tumor-suppressor pathway? Mechanical cues control Hippo-YAP/TAZ tumor-suppressor pathway The Hippo signaling pathway is a complex network of proteins that controls organ size via regulation of cellular proliferation, survival and differentiation. [...]
Which biochemical pathways are regulated by mechanical signals?
Which biochemical pathways are regulated by mechanical signals? Biochemical Mechanotransduction Cells are capable of relaying mechanical stimuli from their physical environment all the way down to the nucleus through electrochemical, biochemical or mechanical pathways. [...]
Ding Wei Yung
Alumni
Principal Investigator
Research Interests
Cell-Matrix and Cell-Cell Mechanotransduction, Molecular Mechanisms of Mechanobiology
Wei Yung’s interest lies in understanding the sophistication of cells as robust machines. Using C. elegans, a 1mm nematode, as a model system, he investigates the cellular machinery underlying newly fertilized zygotes that drives critical force-dependent processes such as polarization and cytokinesis.
Biography
Wei Yung completed his Bachelor’s degree in Bioengineering (Second Class Upper) from the National University of Singapore in 2012. In his honors dissertation under the co-supervision of Professor James Goh and Professor Wong Hee Kit, he optimized the conditions required for the construction of interbody spinal fusion device using primary adipose stem cells seeded in a biodegradable polycaprolactone/tricalcium sulphate (PCL/TCP) scaffold. The work was presented in the Bioengineering Showcase 2012 and he was awarded the Best Poster Award. After he was enrolled in the Mechanobiology Graduate Program, he joined Dr. Zaidel-Bar’s Cell Adhesion and Morphogenesis Lab and is currently searching for novel genes involved in regulating C. elegans early embryogenesis.
