What are epithelial tubes? Tubulogenesis, or the formation of tubes, is one of the fundamental morphogenetic events taking place during development. Several major organs, such as the respiratory, circulatory, and secretory systems, are constituted [...]

What is cell migration? Cell migration is the directed movement of a single cell or a group of cells in response to chemical and/or mechanical signals. It is a fundamental cellular process that occurs [...]

What is cell polarity? Cell polarity refers to the intrinsic asymmetry observed in cells, either in their shape, structure, or organization of cellular components. Most epithelial cells, migrating cells and developing cells require some [...]

How is tubulogenesis regulated by mechanics? The basic steps during tube formation, including cell polarization, the formation of small multiple lumens and the coalescence of multiple lumens into a single lumen, and subsequent tube [...]

What is the cellular origin of hematopoietic stem cells? Based on findings from a large number of anatomical, biochemical, and genetic studies carried out over the years, three major theories have been put forth [...]

How is hematopoiesis regulated by mechanics? Once blood circulation is established during the earliest stages of hematopoiesis, the pulsatile nature of blood flow within the aorta generates a range of biomechanical forces, such as [...]