How do Focal Adhesions Sense the Physical Properties of the Matrix?
How do Focal Adhesions Sense the Physical Properties of the Matrix?Based on the hypothetical protein switches, two models (1 and 2 below) have been put forth to describe the physical mechanism of focal adhesion mechanosensitivity [...]
Spatiotemporal control of DNA, RNA, protein and lipid synthesis
Spatiotemporal control of DNA, RNA, protein and lipid synthesisIn eukaryotes, synthesis of DNA, RNA, proteins and lipids is performed in a spatiotemporal manner. Each molecule is produced within specialized organelles or compartments with strict regulatory [...]
Protein Localization
Protein LocalizationIn order for subcellular processes to be carried out within defined compartments or cellular regions, mechanisms must exist to ensure the required protein components are present at the sites and at an adequate concentration. [...]
The Cell
The CellCells are the basic units of life; small machines that facilitate and sustain every process within a living organism. Muscle cells contract to maintain a heartbeat and allow us to move, neurons form networks [...]
Actin Filaments
What are actin filaments? Actin filaments (F-actin) are linear polymers of globular actin (G-actin) subunits and occur as microfilaments in the cytoskeleton and as thin filaments, which are part of the contractile apparatus, in [...]
What is actin nucleation?
What is actin nucleation? The first step in actin polymerization is known as ‘nucleation’. This step sees the formation of an actin nucleus, which is essentially a complex of three actin monomers, from which [...]
