Bibhas ROY
Visiting Research Fellow, Mechanobiology Institute, National University of Singapore, Post-doctoral Fellow, FIRC Institute of Molecular Oncology (IFOM), Italy
mbibr@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
Ng Pei Ying
Research Fellow, Holle Group
Welcome aboard, Boon Heng!
The Chan Lab welcomes Boon Heng, the first PhD student to the lab. Looking forward to exciting times ahead!
Farewell to Nicole, our first summer intern in the Lab!
Congrats to Nicole for winning the best video presentation in the MBI MUST program. We are lucky to have you! Thank you for bringing so much energy and joy to the lab. Hope to see you soon!
2021 Cell & Tissue Hydraulics: Virtual interactive symposium
REGISTRATION NOW OPEN. The Cell & Tissue Hydraulics Mini-Symposium will present three days of pre-recorded lectures, live talks from invited speakers and pre-recorded short talks and poster presentations.
Spotlight on MBI Prof Low Boon Chuan: Unravelling the chemistry of life
A recent NUS News article features Assoc Prof Low, who leads a dynamic team at MBI focusing on how cells signal – the way they communicate with one another and within themselves.
2021 Bootcamp on Mechanobiology
THIS EVENT HAS BEEN POSTPONED.
Bibhas Roy
Alumni
I am a Research Fellow in Nuclear Mechanics & Genome Regulation Laboratory at MBI. In my doctoral research at Indian Institute of Technology Kharagpur, I have been understanding about the cellular mechanotransduction which specifically deals with cell membrane mechanosensors and consequent downstream cell responses. Eventually I have quite interested on nuclear mechanotransduction because for last two decades several path breaking findings in cellular mechanobiology has gained enormous interest to scientific community, but the nuclear mechanotransduction field remains quite elusive. This drive brought me to Prof Shivashankar’s Lab at MBI.
During differentiation and also reprogramming, cells accumulated multiple epigenetic changes, which leads to differential type of gene expression in different cell types. My current endeavor explores how nuclear geometry driven epigenetic changes leads to different cell type commitment.
Recent Publications
- Yuan L, Roy B, Ratna P, Uhler C, and Shivashankar GV. Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions. Sci Rep 2022; 12(1):17318. [PMID: 36243826]
- Roy B, Yuan L, Lee Y, Bharti A, Mitra A, and Shivashankar GV. Fibroblast rejuvenation by mechanical reprogramming and redifferentiation. Proc. Natl. Acad. Sci. U.S.A. 2020;. [PMID: 32350144]
- Banerjee H, Roy B, Chaudhury K, Srinivasan B, Chakraborty S, and Ren H. Frequency-induced morphology alterations in microconfined biological cells. Med Biol Eng Comput 2018;. [PMID: 30415434]
- Roy B, Venkatachalapathy S, Ratna P, Wang Y, Jokhun DS, Nagarajan M, and Shivashankar GV. Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors. Proc. Natl. Acad. Sci. U.S.A. 2018;. [PMID: 29735717]
