Pallavi Chinnu VARGHESE

Research Fellow, Mechanobiology Institute, National University of Singapore

pallavi_varghese@nus.edu.sg
Level 9 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Pallavi Chinnu Varghese

Research Fellow

Principal Investigator

Jennifer Young

Qualifications

PhD, MSc, BSc

Biography

Pallavi’s long-standing interest in developmental biology drives her research into how mechanical cues shape embryonic development. She completed her PhD at the Rajiv Gandhi Centre for Biotechnology in Thiruvananthapuram, in Dr. Debasree Dutta’s lab, where she investigated the role of the histone chaperone APLF in mammalian embryo implantation.

She then joined Prof. Alexander Medvinsky’s group at the University of Edinburgh as a postdoctoral research fellow, studying how embryonic curvature influences the formation of hematopoietic stem cells in a mouse model.

She is currently a Research Fellow in Dr. Jennifer Young’s group, where her work focuses on understanding the mechanical development of the insect heart.

Selected Publications

  1. Varghese, P. C., & Dutta, D. (2023). Protocol for isolation of mouse pre-implantation embryos for gene expression analysis. STAR protocols, 4(3), 102479.
    https://doi.org/10.1016/j.xpro.2023.102479
  2. Varghese, P. C., Rajam, S. M., Nandy, D., Jory, A., Mukherjee, A., & Dutta, D. (2021). Histone chaperone APLF level dictates the implantation of mouse embryos. Journal of Cell Science, 134(1), jcs246900.
    https://doi.org/10.1242/jcs.246900
  3. Rajam, S. M., Varghese, P. C., Shirude, M. B., Syed, K. M., Devarajan, A., Natarajan, K., & Dutta, D. (2024). Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells. European Journal of Cell Biology, 103(3), 151439.
    https://doi.org/10.1016/j.ejcb.2024.151439
  4. Majumder, A*., Dharan, A. T*., Baral, I*., Varghese, P. C*., Mukherjee, A., Subhadradevi, L., Narayanan, G., & Dutta, D. (2019). Histone chaperone HIRA dictate proliferation vs differentiation of chronic myeloid leukemia cells. FASEB bioAdvances, 1(9), 525-537.
    https://doi.org/10.1096/fba.2019-00014
  5. Rajam, S. M., Varghese, P. C., & Dutta, D. (2022). Histone Chaperones as Cardinal Players in Development. Frontiers in Cell and Developmental Biology, 10, 767773.
    https://doi.org/10.3389/fcell.2022.767773
  6. Baral, I., Varghese, P. C., & Dutta, D. (2022). Epigenetics as “conductor” in “orchestra” of pluripotent states. Cell and Tissue Research, 390(2), 141-172.
    https://doi.org/10.1007/s00441-022-03667-0