YU Miao
Research Fellow, Mechanobiology Institute, National University of Singapore
mbiyum@nus.edu.sg
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411
MBI Researchers Identifies a Signalling Pathway in Stiff Ovarian Tissue Affecting Egg Maturation
A joint study between the Li and Young Labs at MBI, together with A*STAR's Institute of Molecular and Cell Biology, pinpoints the molecular switch responsible for matrix stiffness in ageing ovaries, offering an alternative way to treat age-related infertility without having to reverse stiffness.
MBI to host EMBO Workshop on Cell and Tissue Mechanics of Aging and Regeneration
Organised and hosted by MBI, this EMBO Workshop will be held on 21-24 September 2027 at the Shaw Foundation Alumni House, NUS. Please click on the link to register your interest: https://coming-soon.embo.org/gw27-14
Seeking Research Fellow in Cardiac Organoids and Microphysiological Systems at the Mechanobiology Institute, NUS
The laboratory of Prof. Hanry Yu seeks to to recruit a Research Fellow in Cardiac Organoids and Microphysiological Systems at the Mechanobiology Institute, NUS.
Yu Miao
Research Fellow
Recent Publications
- Huang M, Chen Y, Liang C, Narayan OP, Stallings C, Yu M, Traugot C, Li L, Li K, Vo Q, Wang H, Chou Y, Cech L, Parra D, Garzon L, Parsons D, Diaz E, Zhang C, Mackey C, Sussman H, Zmirska I, Chung M, Zhou C, Glynatsis G, Siemann DW, Licht JD, Li C, Kaye FJ, Xie M, Tan Y, Wu L, Bivona TG, Guan J, and Tang X. Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability. Biomaterials 2025; 329:123920. [PMID: 41443038]
- Wang Y, Zhang Y, Yu M, Xiu P, Jia Y, Chen H, Le S, Qian J, and Yan J. Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats. Nanoscale Horiz 2025;. [PMID: 40492359]
- Le S, Yu M, Fu C, Heier JA, Martin S, Hardin J, and Yan J. Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction. Proc Natl Acad Sci U S A 2024; 121(37):e2400654121. [PMID: 39236238]
- Zhang Y, Du J, Liu X, Shang F, Deng Y, Ye J, Wang Y, Yan J, Chen H, Yu M, and Le S. Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification. Nat Commun 2024; 15(1):6151. [PMID: 39034324]
- Yu M, Lu J, Le S, and Yan J. Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature. J Phys Chem Lett 2021;:7914-7920. [PMID: 34384021]
- Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD, Jørgensen C, Humphries MJ, and Goult BT. Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. J Biol Chem 2021;:100837. [PMID: 34118235]
- Yu M, Zhao Z, Chen Z, Le S, and Yan J. Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains. Nat Commun 2020; 11(1):4476. [PMID: 32900995]
- Le S, Yu M, and Yan J. Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin-talin/α-catenin linkages. Sci Adv 2019; 5(12):eaav2720. [PMID: 31897422]
- Le S, Yu M, Bershadsky A, and Yan J. Mechanical regulation of formin-dependent actin polymerization. Semin. Cell Dev. Biol. 2019;. [PMID: 31813767]
- Le S, Yu M, and Yan J. Phosphorylation Reduces the Mechanical Stability of the α-Catenin/ β-Catenin Complex. Angew. Chem. Int. Ed. Engl. 2019;. [PMID: 31625226]
